A Retrospective Study On Risk Factors For Hepatitis C Virus Related PLC

AIMS:The aim of the study was to assess the risk factors for the development of PLC among hepatitis C, so as to promote the screening in the high risk populations。METHORDS:A total of 122 patients (70 male,52 female, age 39～83 years old, the average of age 59.9±12.0 years old) were incorporated in this program. This study contains 56 patients with HCV related PLC(the group of PLC),and 66 patients with HCV infection as control(the group of non-PLC).In the group of PLC, there were 44 male and 12 female patients whose average of age was 65.0±8.2 years old. In the group of non-PLC, there were 26 male and 40 female patients whose average of age were 55.5±13.1 years old. All patients underwent Liver function, triglyceride and total cholesterol, blood glucose. HBV and HCV markers test, and the liver, upper spleen ultrasonography.abdominal CT examination.Beckman automatic Automatic biochemical analyzer was used to detect serum biochemical parameters; Quantitative real-time FQ-PCR method was used for detection of serum HCV RNA levels.Unconditional logistic regression was performed to analyze the risk factors by using SPSS 16.0 software.RESULTS:In the group of PLC the porproation of male,age≥65 years old,HBcAb positive and liver cirrhosis were 78.6%,51.8%,72.5% and 71.4%, which were higher than the porproation in the group of non-PLC. In Univariate analysis, the following four factors influenced carcinogenesis with statistical significance:male (p=0.001), age (p=0.005), HBcAb positive (p=0.025), liver cirrhosis (p=0.004).Other factors including HCV load,blood glucose,triglyceride and total cholesterol have already been proven that there not be significant differences between the two groups. With logistic analysis using these four factors, male, age, HBcAb, liver cirrhosis were independent significant risk factors for predicting PLC.The OR of the male patients was 4.846(95%CI,1.905-12.329) compared with female patients;the OR of the patients older than 65 years old is 1.080(95%CI,1.024-1.139) compared with those who were younger than 65 years old;the OR of patients with HBcAb positive was 2.806(95%CI,1.140-6.907) compared with those who were HBcAb negative,and the OR of patients with liver cirrhosis was 3.915(95%CI, 1.542-9.942) compared with those who were only hepatitis but not liver cirrhosis.CONCLUSIONS:Male, liver cirrhosis, HBcAb posotive, elderly(age≥65 years old) are risk factors for development of PLC in Hepatitis C patients.The proporation of genotype 1 hepatitis C virus is the largest among all the patients. The incidence of genotype 1 HCV infection in the group of PLC is higher compared with the group of non-PLC,however,there were no significant difference between the two groups.The relationship between genotype of HCV and PLC in Hepatitis C need futher large sample study.