Analysis Of Risk Factors For Hepatitis B Virus-related Primary Liver Cancer

BackgroundPrimary hepatocellular carcinoma(HCC)is a malignant tumor.It is the fifth incidence of male and the ninth of women in the world,and the incidence of malignant tumors in the world is still rising.About one hundred and ten thousand patients in our country are killed by liver cancer every year.The incidence and mortality of HCC in our country account for more than fifty percent of the global total.And seventy-eight percent of HCC was mainly hepatitis B patients.Specific mechanism of HCC is unknown.It is unknown whether it is related to other factors.A large number of data indicate that the occurrence of liver cancer is related to the infection of hepatitis B virus(HBV).There were many studies on the risk factors related to primary liver cancer at home and abroad,and there was not much research on the risk factors of HBV-related HCC.In this study,the risk factors of HBV-related primary liver cancer were analyzed.ObjectiveIn order to explore the risk factors of HBV-related primary liver cancer,the clinical data of patients with hepatitis B virus infection in Pingmei Shenma Medical Group Hospital was analyzed through a retrospective analysis.MethodThe clinical data of 205 patients with HBV infection in Pingmei Shenma Medical Group Hospital from January 2011 to October 2017 was selected.There were 171 males and 34 females,aged 25 to 80 years,average 52.7 years old,the standard deviation was 10.93 years old.Among which 136 cases were aged from 40 to 60 years old,51 cases of more than 60 years old,and 18 cases of less than 40 years old.Divided into HBV-related liver cancer group and HBV-related liver disease group.According to the antiviral treatment at the first visit,HBV-related liver cancer group was divided into antiviral treatment group and non-antiviral treatment group.Record them separately in each group.They are age,gender,history of drinking,poor eating habits,history of diabetes,hepatitis B viral load(HBVDNA),e antigen(HBeAg),hepatitis B course,family history of hepatocellular carcinoma,fatty liver,a tire protein(AFP),glycosylated hemoglobin(HbA1c),alanine aminotransferase(ALT),aspertate aminotransferase(AST),total bilirubin(TBIL),albumin(ALB),prothrombin time(PT),antiviral treatment,HBVDNA change after antiviral treatment,recurrence of hepatocellular carcinoma,liver disease happened in the group of liver cancer and groups of cases of follow-up.Abdominal color ultrasound,CT or MRI findings.Application SPSS 22.0 analysis software,count data using the percentage of cases.Measurement data using mean plus-minus sign standard deviation said.Single-factor analysis was conducted with the chi-square value(or t-value)and multi-factor analysis using logistic regression analysis.The P-value was less than 0.05,there were significant differences,with statistical significance.Result1.Comparison of incidence between HBV-related liver cancer group and HBV-related liver disease group: males 83.4 percent were significantly higher than females 16.6 percent between the two groups.The age group of 40 to 60 was significantly higher than the other age groups(8.8 percent of under 40 years old,24.9 percent of over 60 years old).2.Univariate analysis: The proportion of HBV-related liver cancer group was higher than that of HBV-related liver disease group in bad eating habits,hepatitis B virus load positive,e antigen positive,long-term drinking history,diabetes history,family history of liver cancer,fatty liver and AFP.Two groups of comparisons,the chi-square valuses(or t value)of the above factors were 28.757,22.34,4.075,16.359,11.66,15.267,21.086 and-6.077,respectively.Their P-values were 0.000,0.000,0.044,0.000,0.000,0.000,0.000 and 0.000 respectively.The P-value was less than 0.05,there was a significant difference,which was statistically significant.3.Multivariate logistic regression analysis: Logistic regression analysis showed that age(greater or equal to 40 years old),HBVDNA positive,bad dietary habits,long-term drinking history,family history of liver cancer,diabetes history,and fatty liver,their OR values(95%CI)were 4.434(1.390 to 14.144),4.162(1.884 to 9.196),2.742(1.272 to 5.910),2.395(1.145 to 5.009),3.504(1.320 to 9.303),2.980(1.277 to 6.952),2.781(1.275 to 6.065),respectively.Explain that the above factors were related to HBV-related liver cancer.Among which the most relevant were age(greater or equal to 40 years),HBVDNA positive,and family history of liver cancer.4.Comparison of mortality and survival rates between antiviral and non-antiviral therapy in HBV-related hepatocellular carcinoma: One-year mortality rate(59.1 percent)in the non-antiviral treatment group was significantly higher than that in the antiviral treatment group(26.8 percent).Three-year and five-year survival rates(34.1 percent,6.8 percent)were lower than those in the antiviral treatment group(58.9 percent,14.3 percent).There was a significant difference in the three-year and five-year survival rates between the two groups(P-value less than 0.05).ConclusionHBVDNA positive,age(greater or equal to 40 years old),diabetes history,long term drinking history,family history of liver cancer,bad eating habits and fatty liver may be the risk factors for the occurrence of HBV-related liver cancer.The most likely risk factors were age(greater or equal to 40 years),HBVDNA positive,and family history of liver cancer.