| Objective:1.After the study of radiofrequency ablation treated primary liver cancer liver, radiofrequency ablation affected the situation of biochemical indexes and the incidence of complications which is to investigate the safety of treatment of liver cancer.2.After the study of radiofrequency ablation treated primary liver cancer liver, radiofrequency ablation affected the change of AFP, the status of a single tumor complete necrosis rate and the status of survival time and survival rate which are used to investigate the treatment of liver cancer patients.3.After radiofrequency ablation treated primary liver cancer liver, we analyze the relationship between survival time, survival rate and tumor size, tumor number, tumor location, liver function, cirrhosis, liver cancer stage, preoperative AFP which are used to investigate healing effect.Methods:Application of radiofrequency ablation technology in the VIP department of the First Affiliated Hospital of Kunming Medical College Surgical treatment from August 2005 to December 2010,67 patients unwilling, unable or not surgical treatment of primary liver cancer patients with radiofrequency ablation and their retrospective analysis of clinical data.Results:1. Radiofrequency ablation treated primary liver cancer patients, by radiofrequency ablation after 1 week ALT and AST were significantly higher than that before, but 2 weeks restored to the preoperative level.2. Radiofrequency ablation treated primary liver cancer patients, preoperative AFP positive HCC patients blood AFP values after 2 weeks most of the decline in varying degrees3. The complications of radiofrequency ablation treating primary liver cancer: fever in 20 cases (29.85%), Local pain in 26 cases (38.80%), nausea and vomiting in 6 cases (8.95%), Perihepatic peritoneal fluid in 2 cases (2.98%), pleural effusion in 2 cases (2.98%), electrode skin burns in 1 case (1.49%)..4. Radiofrequency ablation treated the 67 patients of primary liver cancer which has a total of 95 tumors. Complete necrosis rate after a single radiofrequency ablation is 73.68%(70/95), in which:complete necrosis rate of a single ablation in less than 3.0cm in diameter is 89.36%(42/47); complete necrosis rate of a single ablation between 3.1 to 5.0cm in diameter is 68.57%(24/35); complete necrosis rate of a single ablation in more than 5.0cm in diameter is 30.76% ablation (4/13).5. After radiofrequency ablation treated primary liver cancer patients, the cumulative survival rates of 1,2,3 and 5 years were 85%,74%,57% and 44%. After radiofrequency ablation treated primary liver cancer patients in less than 3.0cm in diameter, the cumulative survival rates of 1,2,3 and 5 years were 88%,82%,68% and 56%.6.67 patients with radiofrequency ablation of primary liver cancer patients analyzed factors that may affect its efficacy. The results showed that the prognosis of primary liver cancer by radiofrequency ablation had nothing to do with age, gender, tumor number, preoperative AFP, treatment times, which the prognosis was related to tumor size, tumor location, Child-pugh classification of liver function, whether cirrhosis, liver cancer staging, with or without combination with other treatment.Conclusions:Radiofrequency ablation treated primary liver cancer, which has minimum trauma, few complications and high security. Some patients are unwilling or unable to tolerate hepatic resection among which effective treatment of RFA was provided. Radiofrequency ablation has high clinical value. The prognosis of primary liver cancer by radiofrequency ablation was related to tumor size, tumor location, Child-pugh classification of liver function, whether cirrhosis, liver cancer staging, with or without combination with other treatment. Therefore, select the appropriate treatment of preoperative target, reasonably grasp the indications for treatment, actively improve the patient's liver function, and combine with other treatments at the same time, primary liver cancer by radiofrequency ablation can achieve a better therapeutic effect.
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