Magnetic Resonance Diffusion-weighted Images In Benign ProstaticHyperplasia And Prostate Cancer Diagnosis

BackgroundProstate cancer for men in the United States and Europe is the most c ommon malignant tumor, China and other Asian countries, the incidence is lo w, but showed a significant growth trend in recent years, early diagnosis o f prostate cancer with the clinical diagnosis and treatment is important. prodtate-specific antigen(prostate specific antigen,PSA)is a sensitive in dicator of prostate cancer detection, but its high sensitivity and low spe cificity, can not display the extent of the tumor. Preoperative diagnosis o f prostate cancer is the gold standard for prostate biopsy, but biopsy isa n invasive, and the sampling error due to false-negative rate. Rectal ultra sound and CT imaging in the lack of specificity. General MRIT1WI, T2WI, STIR has good tissue contrast and multiplanar imaging, to better show the prost ate lesions. However, conventional MRI diagnostic accuracy for prostatecan cer remains to be improved, for benign prostatic hyperplasia, prostatitis a nd prostate cancer has been difficult identification. Diffusion-weighted i maging(DWI)as a noninvasive method of examinationof prostate cancer diag-nosis and differential diagnosis of importance, can provide important ref-erence for clinical diagnosis and early treatment of clinical interventi-on to improve the quality of life of patients.ObjectiveMR examination of prostate examination with routine MR imaging plus d iffusion-weighted magnetic resonance diffusion techniques to study of be-nign prostatic hyperplasia, prostate cancer, conventional MR, diffusion-wei ghted imaging(DWI)and apparent diffusion coefficient(ADC)performance and-the ADC values to investigate the diffusion-weighted imaging(DWI) in the diiagnosis of prostate cancer,its pathology provide quantitative diagnos-etic information.MethodsClinical diagnosis of patients with prostate disease(11 patients with pathologically confirmed prostate cancer,27 cases of pathological and fol low-up proved to be benign prostatic hyperplasia)routine MR and diffusio n-weighted imaging, analysis of conventional MR, diffusion-weighted imaging (DWI)and Table View coefficient(ADC)map the performance. DWI imaginginthe scanning and will enter GEADW4.4 and Leonardo workstation applications, t-he ADC values of ROI measurement, ROI measurement lesions choice of fixed maximum display level 3 on the average ADC value of the interestarea. To t he organization and the apparent diffusion coefficient lesion were statis tically analyzed and compared during the existence of significant differe nces.Result1. Prostate plus diffusion-weighted conventional MR images(DWI)and ap-parent diffusion coefficient(ADC)can clearly show the prostate peripheral zone and central zone. Benign prostatic hyperplasia in the peripheral zone more uniform signal in the conventional T2WI and DWI images are high sig-nal, the central band signal due to uniform glands in the conventional T2-WI and DWI images showed heterogeneous high signal, lower signal for them-uscle fiber hyperplasia. Prostate cancer is lower in conventional T2WI s-ignal, DWI showed high signal on the image, ADC map showed low signal.2. Prostate value of diffusion-weighted images with b=800s/mm2 with bv-alues=0s/mm2 best ADC maps were measured in benign prostatic hyperplasia a nd prostate cancer groups in the peripheral zone and central zone, bladder , seminal vesicles, obturator muscle ADC values the organizations did not d iffer between the ADC values (P>0.05). Prostate gland hyperpasia and musc-le fiber is divided into two kinds of tissue were measured gland hyperpl-asia, proliferation of muscle fibers between the ADC value was significant between the difference was statistically significant. Prostate peripheral zone and central zone (glandular hyperplasia, muscle hyperplasia). There w-ere significant differences between the ADC values. Peripheral zone inpro-state cancer and benign prostatic hyperplasia in the peripheral zone and central zone (glandular hyperplasia, muscle hyperplasia) ADC values were significantly different. Prostate cancer and benign prostatic hyperplasia statistically significant difference between the groups.Conclusion1.A magnetic resonance diffusion-weighted images and ADC values can p rovide quantitative diagnosis of prostate cancer diagnostic information,a nd convenient, simple,routine prostate cancer as an adjunct to identify p-rostate cancer. ADC values to distinguish between prostate cancer and non-reliable indicator of tumor tissue.2. Combined with conventional magnetic resonance diffusion-weighted i-maging, MR morphological changes in the routine, based on the combination o f DWI lesion signal characteristics of the map and the pathological chan-ges of ADC values to provide the characteristics of diagnostic imaging of prostate cancer can increase the compliance rate and specificity.3. MR diffusion imaging diagnosis of prostate cancer has important si-gnificance map of prostate cancer in the DWI showed high signal, low sign-al on ADC map, which ADC was significantly lower than benign prostatic hy-perplasia in the peripheral zone and central zone tissue and prostate ca-ncer. The differential diagnosis and early diagnosis is important.4. Three tissue prostate hyperplasia (stromal hyperplasia, glandular hy-perplasia, mixed hyperplasia) in the DWI and ADC map show different, the AD C value of the response characteristics of three kinds of pathological h-yperplasia.