The Clinical Reseach About The Efficacy Of Hanwenbingyong(Warming-Yang, Removing-Toxicity And Activating-Blood) Therapy In Acute Myocardial Infarction

Objectiive To observe the efficacy of Warming-Yang, Removing-Toxicity and Activating-Blood therapy therapy in Acute Myocardial Infarction(AMI), and to explore its possible mechanism.To confirm the feasibility of Warming-Yang, Removing-Toxicity and Activating-Blood therapy therapy treating AMI.Methods 60 cases of AMI patients were randomly divided into two groups: experimental group and control group. All the patients of two groups were given standard undifferentiated treatment of the modern medicine, including:general medical treatment such as drug treatment (Clopidogrel, Aspirin, UFH/LMWH,β-receptor blocker, ACEI/ARB etc.) and PCI or Intravenous thromolysis, the treatment of other related complication, for example Heyertension, Diabetes and Lipid disorders. At the same time, patients of the experimental group were given the decoction of Hanwenbingyong(Warming-Yang, Removing-Toxicity and Activating-Blood) Chinese Herbs (Radix bupleuriiog 10g Ramulus cinnamomiiog 10g Radix scutellariae 15g Fructus forsythia 15g Radix codonopsis 20g Rhizoma pinelliae 10g Bulbus allii macrostemonis 15g Rhizoma chuanxiong 10g Radix salvia miltiorrhiza 15g Radix glycyrrhiza 6g), patients of control group were given the decoction of Removing-Toxicity and Activating-Blood Chinese herbs (Radix salvia miltiorrhiza 10g Dalbergia odorifera 10g Rhizoma chuanxiong 15g Radix paeoniae rubra 15g Flos carthami 15g Radix scutellariae 15g Fructus gardenia 15g Fructus forsythia 15g). The treatment last two weeks (14 days). And then, assess the affects through evaluating clinical symptoms and signs integral, measuring the concentration of C-reactive protein, Fibrinogen and White blood cells, comparing that after treatment with before, and that of the experimental group with control group, to abserve afficacy of Hanwenbingyong Chinese herbs in AMI and to explore the possible mechanism.Results: After two weeks of treatment, both groups have reached a higher efficiency(Experimental group:96.67%, control group:93.33%); The concentrations of C-reactive protein and White blood cells decreased significantly, each differences of both groups were statistically significant (P＜0.01).Compared with the control group, the decreased value of the experimental group was statistically significant (P＜0.01). The concentrations of FIB rised after treatment. Differences of both groups in clinical symptoms integral were statistically significant (P＜0.01) after treatment compared with before, the decreased value of the experimental group was statistically significant(P＜0.01). Differences of both groups in symptoms and signs integral of ACS and Blood Stasis were statistically significant (P＜0.01), but the decreased value of both groups were statistically significant (P>0.05)Conclusion:With the standard treatment of modern medicine, Warming-Yang, Removing-Toxicity and Activating-Blood therapy therapy Chinese Herbs can reduce patient' s inflammatory response effectively to stable unlnerable plaque, to protect vascular endothelial cells, to inhibit thrombosis, showing the feasibility of Warming-Yang, Removing-Toxicity and Activating-Blood therapy therapy treating AMI. And no obvious adverse reaction was found during the medication.