The Short And Long Term Therapeutic Observation About The Stained-release Fluorouracil For Implant For Malignant Tumors Of Ovary

Objective:To observe the short and long term therapeutic about the sustained-release fluorouracil(5-FU) for implant for malignant tumors of ovary.Methods:67 patients with malignant tumors of ovary,were divided into controlled group(32 cases) and treatment group(35 cases).The control group received conventional chemotherapy 2 weeks after the surgery.For the treatment group,the sustained-release 5-FU were implanted during operation,and received chemotherapy 4 weeks later. To compared the differences between the various indicators of the two groups about the short and long term therapeutic.Results: The short term therapeutic:1)The number of the treatment group of patients with tumor progression and recurrence was less than that of the control group(P<0.05); 2)39 of the 67 cases had measurable lesions left after surgery,and for the 39 cases,the therapeutic effective rate of the treatment group(21 cases) was higher than that of the control group(18 cases)(P<0.05). The long term therapeutic: 1)There was no obvious difference of the overall survival rate(1, 2, 3 years) between the treatment group and control group(P<0.05);2)1 year non-progression survival rate of the treatment group was higher than that of the control group(P<0.05), however, 2 and 3 years non-progression survival rate of the treatment group and control group did not obviously differ from each other(P>0.05); 3)There were 38 cases had measurable lesions left after surgery(1 case of censored data removed),among the 38 cases,progression-free survival of the treatment group (20 cases) longer than that of the control group (18 cases)(P<0.05). Conclusion: The sustained-release 5-FU implanted during operation might reduce the progression and recurrence rate of the patients with malignant tumors of ovary shortly after surgery, enhance the efficiency of treatment, improve the non-progression survival rate at 1 year,and prolong progression-free survival time.As the number of samples and the time of follow-up observation were very limited, the survival rate of patients over 3 years and the impact combined with other treatment needed the further observation and research.