| Objective To investigate the genetic polymorphisms of children with Kawasaki Disease (KD) and that complicated with coronary artery lesion (CAL) in theβ-Fibrinogen gene-148C/T (Fgβ-148C/T) and theβ-Fibrinogen gene-455G/A(Fgβ-455G/A).Methods 47 cases of patients with KD and 60 healthy children as controls were studied in this research. Polymorphism analysis of these genes (Fgβ-148C/T and Fgβ-455G/A respectively) were detected with polymerase chain reaction-restriction fragment length polymorphism method (PCR-RFLP).Results (1) For theβ-Fibrinogen gene-148C/T, there were no significant differences between genotype frequency of CC, CT and TT types in KD and healthy controls (χ2=4.194, P>0.05). There was no significant difference between allele frequency of C and T types in KD and controls (χ2=2.64, P>0.05). The CT genotype in KD patients with CAL is significantly higher than that without CAL (χ2=7.009, P<0.05). There were no significant difference between allele frequency of C and T types in KD complicated with CAL and without CAL (χ2=0.862, P> 0.05). (2) For theβ-Fibrinogen gene-455G/A, there were no significant differences between genotype frequency of GG, GA and AA types in KD and healthy controls (χ2=4.194, P>0.05). There was no significant difference between allele frequency of G and A types in KD and controls (χ2=2.64, P>0.05). The GA type in KD patients with CAL is significantly higher than that without CAL (χ2=7.009, P<0.05). There were no significant difference between allele frequency of G and A types in KD complicated with CAL and without CAL (χ2=0.862, P>0.05).Conclusions (1) The polymorphisms of the (3-Fibrinogen gene-148C/T and theβ-Fibrinogen gene-455G/A had not been found association with the pathogenesis of KD. (2) The polymorphisms of CT type of theβ-Fibrinogen gene-148C/T might be related with KD complicated with CAL. (3) The polymorphisms of GA type of theβ-Fibrinogen gene-455G/A might be related with KD complicated with CAL...
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