Chronic Osteomyelitis In Our Hospital Pathogen Distribution And Drug Resistance Analysis

Objective: To analyze the lesions in patients with chronic osteomyelitis inour hospital pathogen distribution and drug resistance, to provide reasonableguidance for clinical treatment and the cause of culture-negative bacteria.Methods: Retrospective analysis of our hospital from January 2008 toDecember 2010 admitted 60 patients with chronic osteomyelitis in patients withthe results of bacterial culture and drug sensitivity test data and for statisticalanalysis.January 2008 to December 2010, our hospital patients were treated 115patients with chronic osteomyelitis, line pathogenic examination of patientswere 60 cases, we selected a sample of these 60 cases. In which 54 male and 6females. Minimum age 13 years, maximum 81 years, an average of 39 years.55 patients with traumatic osteomyelitis, of which 50 patients received variousforms of post-traumatic internal fixation. 5 cases of blood-borne. Disease areas:the femur in 20 cases, 25 cases of tibia and fibula in 12 cases, 6 cases ofhumerus, radius bone in 2 cases, 2 cases of the talus, ulna, calcaneus, phalanxin 1 case.Search in our hospital from January 2008 to December 2010 admitted tomedical records of all patients with chronic osteomyelitis, selected fromeligible cases, the medical records of patients selected for the general situation,diagnosis and treatment of cases, bacterial culture and drug sensitivity testresults of each record.Data were collected will be made into tables, using X2 test was used foranalysis.Results: 60 patients with chronic osteomyelitis, 39 cases were positive for bacterial culture, were cultured 46, 15 pathogens, including one case ofcultured 3, 5 train 2, 33 patients cultured plant; Gram Gram positive (G +)bacteria 25, Gram-negative (G-) 21 strains of bacteria, most bacteria resistant toantibiotics. The positive rate of bacterial culture, 65% (39/60), the study ofsimilar positive rate between 80.1% -86.6%, indicating that the positive rate ofbacterial cultures in our hospital was low. The hospital 60 cases ofosteomyelitis in patients with lesions in the isolated 15 kinds of 46 pathogens,G + cocci 25, accounting for 54.3%, G-bacteria 21, accounting for 45.7%, G +cocci Staphylococcus aureus 15, only 32.6% of the total strains, 1 strain ofhemolytic streptococcus, accounting for 2.2%, 65.2% of other bacteria.Distribution of bacteria in chronic osteomyelitis, there is a greater change stillfirst in Staphylococcus aureus infection, but significantly reduced theproportion of total, Gram-negative bacteria infection rate increased, particularlyin Pseudomonas aeruginosa and Enterobacter cloacae higher infection rate.Staphylococcus aureus infections on the rise. Hematogenous osteomyelitis andtraumatic osteomyelitis of the ratio of 11 to 1, most patients received openreduction and internal fixation.Conclusion: The etiology of chronic osteomyelitis of trauma, surgery andthe use of the plant has become a major cause of chronic osteomyelitis.Distribution of bacteria in chronic osteomyelitis changed greatly, the existenceof multiple infections, S. aureus infections still first, but in the overallproportion decreased significantly increased Gram-negative bacteria infection,especially in Pseudomonas aeruginosa and Enterobacter cloacae infection rateis higher. Staphylococcus aureus infections on the rise. Most of bacterialresistance to antibiotics. The positive rate of bacterial culture in our hospital issignificantly lower bacterial culture methods should be improved to carry outanaerobic bacterial culture and L-type, and derived methods of improvement.The treatment of chronic osteomyelitis should be chosen based on susceptibility test results sensitive to antibiotics, with particular attention to the use of newantibiotics to develop a reasonable treatment.