Study Of Visual Acuity And Visual Function With Amblyopia In Older Children In Six Hours And Full-time Occlusion And After Medication

Aim1. To investigate that the difference of visual acuity and titmus stereopsis in children aged 9 to 12 years with hyperopic anisometropic amblyopia in 6 hours occlusion and full-time occlusion treatment.2. To investigate that the difference of visual function in the group of oral CDP-choline combined occlusion and the group of occlusion in children aged 9 to 12 years with hyperopic anisometropic amblyopia in 6 hours occlusion and full-time occlusion treatment.Method1.150 children aged 9 to 12 years with hyperopic anisometropic amblyopia. According to mild, moderate and severe of amblyopia, we randomized these children in two groups respectively. One is the group of 6 hours occlusion, the other is the group of full-time occlusion. Two groups were received near-vision activities and followed up at months 1,4and10. At these followed up time we recorded the best spectacle-corrected visual acuity and spectacle-corrected Titmus.2. According to mild and moderate of amblyopia, we randomized the two groups of occlusion in the group of oral CDP-choline combined occlusion and the group of occlusion respectively after 10 months. All groups were followed up 4 months and recorded P-VEP, Titmus and CS. Besides, we strictly monitored possible adverse reaction to CDP-choline.3. Results of visual acuity and visual function were analyzed by SPSS 11.5.Results1. The improvement of visual acuity of mild, moderate amblyopia with 6 hours occlusion and full-time occlusion is no significant difference (P>0.05). The improvement of titmus stereopsis of mild, moderate amblyopia with 6 hours occlusion and full-time occlusion have significant difference (P<0.05).2. The P-VEP of moderate amblyopia with the group of oral CDP-choline combined occlusion and the group of occlusion have significant difference (P<0.05). The titmus stereopsis in the group of 6 hours occlusion, the group of oral CDP-choline combined occlusion and the group of occlusion have significant difference (P< 0.05). The titmus stereopsis in the group of oral CDP-choline combined occlusion, the group of 6 hours occlusion and the group of full-time occlusion have significant difference (P<0.05). Contrast sensitivity for CDP-choline treatment to improve visual function in patients with amblyopia to provide reference.Conclusion1. The improvement of visual acuity of mild, moderate amblyopia with 6 hours occlusion and full-time occlusion is no significant difference for children aged 9 to 12 years with hyperopic anisometropic amblyopia. The improvement of titumus stereopsis in 6 hours occlusion is better than full-time occlusion.2. On the base of occlusion treatment, the CDP-choline taking a supporting role to improve visual function for the patients with amblyopia.