A Short-term Efficacy Study Of Oral Administration Of Folium Sannae In Treatment Of Patients With Ureteral Calculi

BackgroudIn clinical, the urinary calculus is common and is one of the urological surgery most common acute diseases. In our country urinary calculus'incidence rate is 1%-5%, south reaches as high as approximately 5%-10%. Ureteral calculi occupies the uropoiesis is the stone 33%-54%, the overwhelming majority is the kidney stone discharges in the process to pause in the ureter result. The ureteral calculi is located the ureter lower segment about 70%, the patient is very painful and may cause the urine road direct damage, the obstruction, the infection or becomes malignant, even causes the shock. The Chinese medicine is our country history remote tradition medicine, has "very conveninent and inexpensively" the characteristic and the superiority, the Chinese medicine application conforms to our country population quantity to be big, financial circumstance relatively weak national condition. On clinical extremely little uses a Chinese native medicine folk remedy row of stone, but uses a compound prescription row of stone. The senna leaf has obviously presses the smooth muscle creeping motion function, on clinical commonly used in intestinal tract clean or chronic constipation. Treats in the ureterolithiasis process at my branch surgery, the convention makes in front of the technique using the senna leaf the intestinal tract preparation. In clinical, you will see that patient may discharge after the use senna leaf the ureterolithiasis, slightly to several millimeters, greatly to 1 centimeter above. Obviously the senna leaf possibly has presses the row of stone function, also because the senna leaf presses the intestinal tract smooth muscle creeping motion function, therefore, the senna leaf presses a row of stone the mechanism possibly to press the ureter smooth muscle creeping motion with it to concern. In order to cause the more ureterolithiasis patient to obtain the effective economical the treatment, it is necessary to press the row of stone function to the senna leaf to conduct the research. This topic namely bases on this, designs a clinical randomized controlled trial(RCT) research, serves as the innovative attempt for the exploration senna leaf to the ureteral calculi.ObjectiveThe discussion senna leaf clinical presses the ureterolithiasis row of stone curative effect, explores the senna leaf to press a ureterolithiasis row of stone initially the clinical curative effect, makes the discussion for the Chinese native medicine folk remedy at in the ureterolithiasis clinical practice, and builds the foundation for it further effective component extraction.MethodA total of 120 patients with ureteral stones were randomly divided into three groups, each 40 examples, A group (senna leaf group), the senna leaf 10g, the 200ml boiling water soaks the drug; B group (the Tamsulosin group), the Tamsulosin Hydrochloride Sustained Release Capsules (Astellas to manufacture drugs Chinese Limited company) the 0.2mg, the oral administration; C group (blank control group), enjoins patient daily potable water 2000～2500ml. Another each patient provides the diclofenac sodium sustained-release tablets 75mg, arranges when the stone process ache according to must take.If the ache were still unable to endure, returned the courtyard seeing a doctor immediately. The stone expulsion rate, the therapeutic efficacy, the curing rate and the rate of adverse reaction were observed.24 hours after the short-term efficacy study in treatment of patients with ureteral calcui need to examine the type-B ultrasonic and X-ray again.ResultThrough to the senna leaf group, the Tamsulosin group, the blank control group in the upper ureteral calculi, the middle ureteral calculi and the lower ureteral calculi, the discovery of the stone expulsion rate was 7.5% and the curing rate was 2.5% in the in the senna leaf group; The Tamsulosin group was 25% and 10% respectively; The Blank control group was 5% and 2.5%; The senna leaf group, the Tanzania rope Rosin group, the curing rate were statistically significanct differences (P<0.05), The senna leaf group were significantly lower than the control group; The senna leaf group, the blank control group in the stone expulsion rate, the curing rate were statistically insignificanct differences (P>0.05).ConclusionThe oral administration folium sannae treatment ureterolithiasis, the curative effect will compare the Tamsulosin group, the blank control group curative effect in the near future is not remarkable, The senna leaf group were significantly lower than the control group(the Tamsulosin group), three group have effect on the lower ureteral calculi in short-term curative effect, the Tamsulosin group will be especially good to the lower ureteral calculi in short-term curative effect.