Clinical Analysis Of Sanjin Paishi Granule In The Treatment Of Middle And Lower Ureteral Calculi

ObjectiveFrom the clinical indicators and follow-up indicators of ureteral calculi,the clinical efficacy of Sanjin Paishi Granule in the treatment of middle and lower ureteral calculi was discussed,which guided the clinical practice of TCM and provided new ideas for further promoting TCM syndrome differentiation and treatment of ureteral calculi.MethodsProspective randomized controlled trials were used to establish inclusion and exclusion criteria.126 patients were randomized by random number-even method.According to the treatment group:control group=1:1,63 patients in the treatment group and 63 patients in the control group.Both the treatment group and the control group were from the outpatient department and inpatients of the Second Affiliated Hospital of Guangdong University of Traditional Chinese Medicine,Guangdong Province Second Affiliated Hospital.The collection time was 1 year.All patients met the diagnostic criteria and inclusion criteria.Observed indicators include:VAS score,urinary white,red blood cell(urine WBC/RBC)value,white blood cell count(WBC),C-reactive protein(CRP)value,serum creatinine value(Cr),blood urea value,and stones after treatment.Complete discharge rate,partial discharge rate of stones,average time of stone discharge,average time to recurrence,and recurrence rate.The collected data is then entered into a Microsoft Office Excel 2018 worksheet to create the original database.According to the sample content formula of the two sample rate comparison in the group design,the sample size is calculated,takingα=0.05,β=0.1.The SPSS 22.0 is used for statistics,all measurement data are expressed as mean plus or minus standard deviation(x±s).The mean value comparison between the two groups is performed by independent sample t test.First,the homogeneity homogeneity F test is used.If the variance is uniform,the t test is used,such as variance.Inconsistent,use t’ test;self-control mean comparison,using paired t test;all non-normal distribution measurement data expressed in average rank(R)and quartile(P25,P550 P75),compare use Mann-Whitney Utest,and Wiliconxon test for intra-group comparison..The grade data comparison was expressed as frequency(f),percentage(P)or average Ridit value(R)and average rank(R),and the median comparison between the two groups was performed by Mann-Whithey U nonparametric test and Ridit analysis;Four-table data was tested using Fisher x2 test(Exact Probability);data was collected by SPSS 22.0.α=0.05.ResultsGeneral information:A total of 126 patients in this subject met the diagnostic criteria,included in the criteria,and were allowed to be included in the subject.Among them,6 cases of the control group were missing,and 120 cases were actually included.The general situation of the case group:43 males and 17 females,with an average age of 52.4±14.13 years,of which the minimum age of ureteral stones was 24 years old and the maximum was 85 years old.The average stone length is 0.86±0.31 cm,with a minimum of 0.4 cm and a maximum of 1.8 cm.The average pain duration was 1.19±0.64 months,with a minimum of 9 days and a maximum of 3 months.The general situation of the control group:40 males and 20 females,with an average age of 57.7±13.84 years,of which the minimum age of ureteral stones was 25 years old and the maximum was 87 years old.The average stone length is 0.89±0.31 cm,with a minimum of 0.5 cm and a maximum of 1.6 cm.The average pain duration was 1.17±0.61 months,with a minimum of 10 days and a maximum of 3 months.There was no significant difference in the VAS score,urine WBC,urinary RBC,blood WBC,blood CRP,blood Cr and blood BUN between the treatment group and the control group(P>0.05),which was comparable.The two groups of patients were compared with those before treatment.The VAS score,urine WBC,urine RBC,blood CRP,blood WBC,blood Cr and blood BUN were significantly decreased after treatment(P<0.01).After treatment,compared with the control group,the VAS score,urinary WBC,urinary RBC,blood CRP,and blood Cr were significantly decreased in the treatment group(P<0.01),and there was no significant difference in blood WBC and blood BUN(P>0.05).Compared with the control group,the difference of VAS score,urinary WBC,urinary RBC,blood Cr and blood BUN was significantly increased in the treatment group(P<0.01),and there was no significant difference in blood WBC and blood CRP(P>0.05).The total effective rate was 85.00%in the treatment group,which was comparable to that in the control group P>0.05).The efficacy of Sanjin Paishi Granule was slightly better.The average time of stone removal in the treatment group was 32.41±12.21 days,which was significantly different from that of the control group(47.83±13.75 days)(P<0.01).Among the 60 patients in the treatment group,26 patients had recurrence of calculi,and the average recurrence time was 11.11±2.67 months.In the control group,39 patients were followed up for recurrence of calculus in 39 patients.The average recurrence time was 8.08±2.74 months,there was a significant difference Test(P<0.05).ConclusionsThe efficacy of Sanjin Paishi Granule in treating the middle and lower ureteral calculi is equivalent to that of urinary stone,which can significantly reduce the symptoms of patients like pain or hematuria,shorten the time of stone removal and reduce the chance of recurrence.The promotion of Sanjin Paishi Granules can prevent patients from suffering from surgery and reduce the economic burden,which is worthy of clinical promotion.