| Objective:To study the Yuhong Ointment dressing in diabetic foot wound the muscle period of granulation tissue growth role, preliminary elaborate it promote wound granulation tissue growth mechanism, make its curative effect advantage gain better theory basis. On this basis, to promote their use. At the same time to regulate Chinese medicine topical treatment of diabetic foot ulcers more basis. Methods:Choose Wagner grading 2-4 level 60 cases of patients with diabetes foot. After the preliminary detumescence, anti-infection treatment, the wound gradually reduce the necrotic tissue and secretion, the wound has granulation tissue growth began to surface, then randomly divided into control and experimental group. Control group of 30 patients, the use of conventional gauze dressing, Vaseline topical; experimental group of 30 patients, the use of hospital preparations Yuhong Ointment. Both groups treatment for four weeks, compared between the two groups after treatment, the granulation tissue growth, and research of various factors on granulation tissue growth impact. Results:(1)Experimental group,30 patients, including 15 males and 15 females, age (59.97±8.61) years, duration of diabetes was (8.37±7.76), the diabetic foot disease (9.57±13.69) weeks, BMI (23.44±3.82) Kg/m2. The control group,30 cases, including male patients with 18 cases, female in 12 cases, age for 63.93±5.74) years old (plus or minus, duration of diabetes 9.44±5.94) for (in diabetes foot course (plus or minus 7.05±7.92 demand) weeks, BMI (23.04±2.91) Kg/m2. Between the two groups as hematological studies, biochemical examination for P>0.05 compared, were not statistically significant. (2)After 4 weeks of treatment, the use of Yuhong Ointment group than in the group using Vaseline good granulation tissue fill rate, P<0.01, in a statistical significance. (3)The growth of smoking on granulationtissue has obvious effect. Compares the two groups of male patients granulation tissue growth, Whether the experimental group; smokers or granulation tissue growth are better than non-smokers growth slow, P<0.05, was statistically significant. (4)Diabetes foot of poor blood glucose control overall HbAlc level, higher, but HbAlc level between with granulation tissue growth and not related, P>0.05. (5)Whether using Yuhong Ointment or using Vaseline, the use of insulin or oral hypoglycemic combined oral hypoglycemic than single granulation tissue growth for both an advantage, P<0.05, compared with a statistically significant. Conclusion:TCM promote wound healing may be mainly aimed at the influence factors of coagulant function, the Yuhong Ointment on diabetic wound healing effect may be to promote local wound tissue cells secrete various growth factors. Through to a variety of growth factors, and play synergy, promote DNA synthesis, and promote cell proliferation. There is a component of tobacco could vasoconstriction, vasospasm, reduced blood supply, ischemia, hypoxia led to slower growth of granulation tissue, this is why smoking than non-smoking group of granulation tissue growth slow. The rise of HbAlc, causing small blood vessels smooth muscle cell proliferation and dysfunctional endothelial cells, vascular luminal narrowing, resulting in the occurrence of diabetic foot. But granulation tissue growth is not mainly by the blood sugar, so blood sugar is in effect a higher level of diabetes foot wound healing also uncertain than glucose control good healing slowly. Insulin can promote the role of protein synthesis, so use insulin in diabetes foot than good effect of designates orally. Yuhong Ointment in the test study found that it had to promote the growth of granulation tissue, for the further application in its clinical provides theoretical basis, have certain clinical guiding value and theoretical significance to its promotion, worth the mechanism of granulation tissue growth research. |
PDF Full Text Request