Clinical Study Of Xiaoji Decoction On The Serum Vascular Endothelial Growth Factor Of Patients With Advanced Non-small Cell Lung Cancer

BackgroundLung cancer is one of the most dangerous disease to threaten human life and health. As a new treatment method, anti-angiogenesis has curative effect on controling tumor growth and transfer, prolong patient survival time. The vascular endothelial growth factor (VEGF) is known as the strongest and most special angiogenesis stimulating factor, which also be considered as an ideal target for the anti-angiogenesis and antitumor recurrence and metastasis Xiaoji Decoction is produced by professor liu weisheng, which has the effect of invigorating the Spleen, reinforcing the Kidney, removing Blood Stasis and detoxification. Research shows that Xiaoji Decoction can control tumors and inhibit the appearance of transfer. Besides that, it also improve the immune function and the quality of life of patients. More modern research has shown that Scorpio, spreading hedvotis herb, Astragalus, Rheum officnale Baill and Zedoary have the effect of anti-angiogenesis, which are contained by Xiaoji Decoction.Object ivesTo objectively assess the influence of Xiaoji Decoction on the vascular endothelial growth factor of advanced non-small cell lung cancer by oberving the changes of serum VEGF of three groups before and after treatment. Besides that, we assessed the synthetic clinical curative effects of Xiaoji Decoction to cure advanced non-small cell lung cancer by oberserving the tumor size, improvement of clinical symptoms, common living conditions, adverse reaction before and after the treatment.MethodsThe patients were divided into three groups:group Xiaoji Decoction; group chemotherapy; group chemotherapy combined with Xiaoji Decoction. In group Xiaoji Decoction, Xiaoji Decoction was administered per day,and 3 weeks per period. In group chemotherapy, NP or GP project was adapted,3 weeks per period. In group chemotherapy combined with Xiaoji Decoction,the usage and direction were as above. In all the three groups, two periods in sequence was an assessment unit. In all the three groups, the changes of serum VEGF, the tumor size, improvement of clinical symptoms, common living conditions before and after the treatment were observed. We also monitor the changes of blood routine, liver and renal function, ECG to evaluate the safety of the Xiaoji Decoction.ResuItsl.The VEGF value differences before and after treatment in group Xiaoji Decoction and group chemotherapy combined with Xiaoji Decoction has statistical significance (P<0.05), while those in group chemotherapy do not (P>0.05).2. The disease remission rate(CR+PR) of group Xiaoji Decoction is lower than groups chemotherapy and chemotherapy combined with Xiaoji Decoction. The disease control rate(CR+PR+SD) of group chemotherapy combined with Xiaoji Decoction is higher than groups chemotherapy and Xiaoji Decoction, while the difference has statistical significance(P<0.05). The disease control rate (CR+PR+SD) of group Xiaoji Decoction is lower than group chemotherapy and the difference has no statistical significance (P>0.05).3. The improvement rate of clinical symptoms and the Kamofsky scores stability rate(ascend and stable) in group Xiaoji Decoction is higher than group chemotherapy, in group chemotherapy combined with Xiaoji Decoction is higher than group chemotherap, and the differences have statistical significances (P<0.05), while the difference between group Xiaoji Decoction and group chemotherapy combined with Xiaoji Decoction has no statistical significance (P >0.05).4. There is 1 case of nausea and vomiting in group Xiaoji Decoction, which do not have other adverse reaction. The main adverse reactions are gastrointesti-nal reaction, the blood system toxicity, liver and kidney function damage in group chemotherapy and group chemotherapy combined with Xiaoji Decoction.conclus ions 1. Xiaoji Decoction or chemotherapy combined with Xiaoji Decoction can reduce the serum VEGF expression of advanced non-small cell lung cancer, which further revealling that Xiaoji Decoction maybe reduce the tumor angiogenesis by inhibiting the secretion of tumor angiogenesis factor.2. Xiaoji Decoction had certain inhibitory effect on the growth of NSCLC, and it could enhanced the disease control rate combined with chemotherapy.3. Xiaoji Decoction and chemotherapy combined with Xiaoji Decoction have more effect on improving the clinical symptom and quality of life of advanced non-small cell lung cancer than chemotherapy.4. Xiaoji Decoction is safe without the blood system toxicity, hepar and renal functional lesion and cordis damage.