Clinical Research On The Aromatase Inhibitor-associated Bone Loss With The Therapy Of Nourishing The Kidney In Ostmenopausal Patients With Breast Cancer

ObjectivesExploring the efficency of Traditional Chinese Medicine based on the Aromatase inhibitor-associated bone loss in postmenopausal women with breast cancer, so as to provide clinical evidence for the clinical practice.Methods38 cases met the inclusion criteria were randomly divided into 2 groups. Treatment group, of 19 cases:the traditional Chinese medicine nourishing the kidney+exemestane+calcium carbonate D600; control group of 19 cases:Exemestane+calcium carbonate D600. Observed the lumbar spine bone mineral density, estrogen levels after 12 months'treatment and analyze the blood analysis, liver, kidney function and antigens changes every 3 months. All data were analysised by SPSS17.0.Results were expressed as mean±standard deviation, t test were used to evaluation.Result38 cases are put into our research practically, and 1 case of the treatment group was excluded due to the other breast metastasis. So 18 cases in treatment group and control group in 19 cases practically.There is comparability and is not stastistical difference at the general between 2 groups(P> 0.05). After 12 months's treatment, bone mineral density showed significant changes in each groups (P<0.05), the change of bone mineral density was significant between two groups (P<0.05). BMD increased by 0.069% in the treatment group, decreased 0.023% in the control group and this difference was statistically significant (P<0.05); The changes of estradiol 2 levels in the each groups were statistically significant changes (P<0.05)after 12 months's treatment, the inhibition rate of estradiol 2 in testradiol treatment group and control group was 21.59% and 43.21%, respectively, and the difference was not statistically signifycant (P> 0.05).ConclusionThese findings suggest that:compared with the control group, using the method of traditional chinese medicine based on nourishing the kidney can increase a bit of the bone mineral density; The estradiol levels of 2 groups were decreased significant after 12 months's treatment. But by contrasting the control group, the group of using the traditional chinese medicine based on nourishing the kidney has lower descend rate, which suggests that the traditional Chinese medicine based on nourishing the kidney don't counteract the pharmacological action of AIs. After 12 months's treatment, observing the cent changes of Kupperman of treatment group, the traditional chinese medicine has better effect in improving the symptoms of arthralgia, courbature.