| Chinese Patent Medicine(CPM) is one kind of drug with different dosage forms, which is processed for the clinical application according to the specified prescription and craft using Chinese Herb Medicines as raw materials with the guidance of Traditional Chinese Medicine theory, and it has the advantages of safe using, small volume, easy admistration and so on. CPM contains many kinds of chemical compositions and its curative effect is the comprehensive embodiment of role of many kinds of ingredients. The infrared spectrogram can reflect the macro fingerprint characteristics of CPM. It can be used for the understanding and control of the quality of CPM, and can provide the scientific basis for the quality control of CPM. Twenty kinds of CPMs were studied in this thesis by infrared spectroscopy combined with chemometrics methods, and infrared fingerprints of twenty kinds of CPMs were established. This dissertation consists of 6 chapters.Chapter one: Introduction. The research progresses of infrared spectroscopy combined with chemonetrics in CPMs in recent years were summarized with 35 references. The objective and significance of this dissertation were described in brief.Chapter two: The optimization of experimental conditions and the methodological experiment. The experimental conditions of infrared spectroscopy for the analysis of CPM were optimized and the optimum experimental conditions were as follows, particle size of 320 mesh, mixing ratio with KBr of 6:100, quality of 100 milligram, tablet pressing time of 20s, tablet pressing pressure of 70KN. The methodological experiments were carried out under the optimum conditions and the advantage aspects of infrared spectroscopy were found to be good precision, stability and reproducibility.Chapter three: Study on the infrared fingerprints of pediatric cold medicines. The infrared spectrograms of 8 kinds of CPMs belong to pediatric cold medicine samples were determined, respectively. The consistency of the infrared spectrograms of the same CPM was investigated by cluster analysis and similarity degree, and the results show that the infrared spectrograms of samples from the same manufacture and different manufactures were in good agreement. The similarity degrees and artificial neural network(ANN) were applied to classify the 8 kinds of pediatric cold medicines, and the results show that the identification of 8 kinds of CPMs can be achieved by ANN. The infrared fingerprints of 8 kinds of pediatric cold medicines were established by average method.Chapter four: Study on the infrared fingerprints of pediatric cough and asthma medicines. The infrared spectrograms of 3 kinds of CPMs belong to pediatric cough and asthma medicine samples were determined, respectively. The consistency of the infrared spectrograms of the same CPM was investigated by cluster analysis and similarity degrees, and the results show that the infrared spectrograms of samples from the same manufacture and different manufactures were in good agreement. The similarity degree and ANN were applied to classify the 3 kinds of pediatric cough and asthma medicines, and the results show that 3 kinds of CPMs can be classified by ANN. The infrared fingerprints of 3 kinds of pediatric cough and asthma medicines were established by average method.Chapter five: Study on the infrared fingerprints of pediatric anorexia medicines. The infrared spectrograms of 7 kinds of CPMs belong to pediatric anorexia medicine samples were determined, respectively. The consistency of the infrared spectrograms of the same CPM was investigated by cluster analysis and similarity degree, and the results show that the infrared spectrograms of samples from the same manufacture and different manufactures were in good agreement. The similarity degrees and ANN were applied to classify the 7 kinds of pediatric anorexia medicines, and the results show that 7 kinds of CPMs can be classified by ANN. The infrared fingerprints of 7 kinds of pediatric anorexia medicines were established by average method.Chapter six: Study on the infrared fingerprints of pediatric canker medicines. The infrared spectrograms of 2 kinds of CPMs belong to pediatric canker medicine samples were determined, respectively. The consistency of the infrared spectrograms of the same CPM was investigated by cluster analysis and similarity degree, and the results show that the infrared spectrograms of samples from the same manufacture and different manufactures were in good agreement. The similarity degrees and ANN were applied to classify the 2 kinds of pediatric canker medicines, and the results show that 2 kinds of CPMs can be classified by ANN. The infrared fingerprints of 2 kinds of pediatric canker medicines were established by average method.
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