Initial Response To Steroids In Chinese Chidren With Primary Nephrotic Syndrome

Objectives: Primary nephrotic syndrome (PNS) is the most common glomeurlar disease in childhood. On the basis of the patients'response to glueocorticosteroid therapy, PNS has been separated into steroid-sensitive nephritic syndrome (SSNS) and steroid-resistant nephrotic syndrome (SRNS). According to the report from ISKDC and Finland, about 78.10%～82.46% of all children respond to steroid treatment and show favourable outcomes, approximately 17.54%～21.90% of patients are resistant to typical steroid treatment and about 30%～40% may progress to end-stage renal disease (ESRD). However, as we know, recent studies about the ratio of SSNS and SRNS in Chinese has not been established. This study has to talk about the initial response to steroids in Chinese chidren with primary nephrotic syndrome.Methods: 266 patients diagnosed with childhood PNS were recruited into our study at the Department of Pediatrics of Fuzhou General Hospital of Nanjing Command from May 2005 to December 2010, which we had a retrospective analysis about these patients.Results: Of 266 cases, 239 cases were SSNS(89.85%) and 27 cases were SRNS(10.15%). 246 cases (92.48%) could be absence of proteinuria and 20 cases (7.52%) could not be absence of proteinuria within 8 weeks. Of 20 cases, 1 cases (0.38%) could be absence of proteinuria with glueocorticosteroid within 120 days. 9 cases (3.38%) with glueocorticosteroid adding cyclosporine within 29 months. But 10 cases (3.76%) were lack of remission with glueocorticosteroid adding other immunosuppressive agents.Conclusion: For the flrst time we reported the incidence of SSNS was 89.85% and SRNS was 10.15% in Chinese children of PNS.