Huang Lian And MuXiang Compatibility Type Of Ulcerative Colitis In Rats Models And Mechanisms Of Intervention Effect

Objective:This study aimed to change HuangLian and MuXiang compatibility with ulcerative colitis rat model of damp-heat in the intervention, while exploring rat colon SOD, MDA, Gin, TNF-a content of change and intervention of the HuangLian and MuXiang relevance.Methods:SD rats 90, male and female were randomly divided into 9 groups, divided into blank group, model group, positive medicine group, HuangLian group, MuXiang group, HuangLian and MuXiang 1:1 compatibility group, HuangLian and MuXiang compatibility group 2:1,4:1 HuangLian and MuXiang compatibility group, HuangLian (Health) and MuXiang 1:1 compatibility group. In addition to the control group, the rest are used trinitrobenzene sulfuric acid (TNBS)/ethanol enema ulcerative colitis established. To HuangLian, the proportion of wood by pre-configured boiling water, adjust the drug concentration is 350mg/ml. Made film from the 1st day after the model group daily with saline, positive drug gentamicin sulfate injection group 28mg/kg/day treatment group 350mg/kg/day orally for 8 days. Observations:body weight, stool consistency and occult blood, DIA, the pathological changes of the colon, colonic SOD, MDA, Gin, TNF-a content.Results:â‘ model group were needy, lazy action, weight loss, then quality Qingxi, UC oid pus and blood will be part of the rats; model rats showed a different degree of colon injury, colon congestion observed the naked eye, erosion, multiple edema formation, and even intestinal necrosis; light microscope, colon luminal epithelial shedding, necrosis, inflammatory cells in the subm UC osa can be seen, suggesting that is UC cessful model.â‘¡model group, the colonic tissue superoxide dismutase (SOD) content is lower than the control group, positive control group and treatment group than the model group, but lower than the control group, in which positive drug group, HuangLian and MuXiang 1:1 compatibility group, HuangLian and MuXiang 2:lcompatibility group was most obvious.â‘¢model group, positive medicine group, the treatment group than the normal colon tissue MDA group, but the model group was higher than positive control group and treatment group, in which the positive control group, HuangLian and MuXiang 1:1 compatibility group, HuangLian and MuXiang 2: 1 compatibility group was most obvious.â‘£model group, serum levels of tumor necrosis factor (TNF-a) was higher than the normal group, positive medicine group and treatment group was lower than the model group, of which the HuangLian group, HuangLian and MuXiang 2:1 shows the most compatibility group obvious. Model group, positive medicine group, treatment group colonic UC osa glutamine (Gin) lower than the normal group, the MuXiang group, HuangLian and MuXiang compatibility group 1:1,2:1 Copt is compatibility group with the closest MuXiang control group.Conclusion:Copt is, MuXiang modeling can improve the compatibility of colon disease activity index can significantly colon of ulcerative colitis model MDA, TNF-a serum levels, increased SOD, Gin content, and compatibility with Pistachio Hong into a certain relevance, this study suggests that Xiang Lian Wan on ulcerative colitis may be related to the promotion of intestinal mUCosal barrier repair, play against peroxidation.