Research On Correlations Among TCM Common Type Of Syndromes And Laboratory Index In 1260 Patients With CHB

ObjectiveTo research the relationship among the TCM syndrome of chronic hepatitis B, viral serum markers and indexs of liver function etc. Explore the internal rule between the TCM syndrome of CHB and laboratory index in order to supply certain basis to further study of objectifying TCM syndrome and TCM syndrome differentiation treatment of CHB.MethodsUsing the chronic hepatitis B TCM regularity syndrome case report form (CRF),with the information collected by 8 clinical unite, analysed and classified by at least 5 TCM experts. While through the process, all the diagnostic criteria, inclusion criteria and exclusion criteria were strictly in accordance with Chronic Hepatitis B Prevention and Curation Journal, which was issued at Dec.2005, by C.M.A. Hepatology Medical Association jointly with C.M.A. Infectious Disease Branch. The process were detecting and recording hepatitis B markers, liver function values and so on, using spss 13.0 medical statistics software to analyse these data by using t test, variance analysis, and count data inclusion test (α=0.05).With all the efforts, it can be revealed the relationship among hepatitis B common TCM syndrome and various detecting markers.ResultsA total of 1260 cases met the inclusion criteria were included. After data analyse, it refered that(1) The first 10 TCM syndromes were dampness-heat-in-spleen-and-stomach>dampness-heat-in-liver-and-gallblader>dampness-heat-in-liver-and-spleen>1 iver-qi-depression-in-and-spleen-deficency>qi-depression-and-heat-in-liver-and-stom ach>spleen-qi-deficiency>liver-qi-depression>dampness-heat-with-stagnation-of--blo od-in-liver-and-gallblader>qi-depression-and-heat-in-liver-meridian>dampness-stagn ation-due-to-spleen-difeciency.(2)The hepatitis B markers of the top 10 TCM syndromes were significantly different (p<0.01), further more, patients with Hbs-Ag+ /eAg+/cAb+were more likely to be found in dampness-heat-in-spleen-and-stomach syndrome group (89 cases), dampness-heat-in-liver-and-gallblader syndrome group (68 cases), and dampness-heat-in-liver-and-spleen syndrome group (66 cases), taking a portion of 17.7%; while, patients with HBsAg+/Anti-HBe+/Anti-HBc+were preferd to be found in dampness-heat-in-liver-and gallblader syndrome group (63 cases), dampness-heat-in-spleen-and stomach syndrome group (60 cases), and dampness-heat-in-liver-and spleen syndrome group (53 cases), holding the part of 13.96%; Thus it refered that the 3 TCM syndrome groups,dampness-heat-in-spleen-and-stomach syndrome, dampness-heat-in-liver-and-gallblader syndrome and dampness-heat-in-liver-and-spleen, had the most active viral replication.(3) The HBV-DNA marks of the top 10 TCM syndromes were not sinigicantly different (P>0.05). (4)The correlation of the top 10 TCM syndromes with indexes of ALT, AST, TBIL, DBIL, IBIL, TP, ALB, ALP were sinificantly different (p<0.01), but were not significantly different with marks of GLB and Cholinesterase (P>0.05). (5)The ALT and AST marks of dampness-heat-in-liver-and-gallblader syndrome and dampness-heat-with-blood-stagnation-in-liver-and-gallblader syndrome were signify-cantly higher(P<0.01) than other syndrome group. (6) The significantlly higher(P<0.01) of TBil, DBil and IBil were mainly seen in dampness-heat-with-blood-stagnation-in-liver-and-gallblader, dampness-heat-in-liver-and-gallblader, and dampness-heat-in-spleen-and-stomach than other TCM syndromes.(7) the TP, ALB, value of ALP in normal reference range.Conclusion(1) Obtained the common chronic hepatitis b patients with TCM syndrome type and the regularity of the laboratory index in order to TCM differentiation and treatment for reference. (2)Patients with patients with HbsAg+/eAg+/cAb+and HBsAg+/Anti-HBe+/Anti-HBc+were mainly seen in dampness-heat-in-spleen-and-stomach,dampness-heat-in-liver-and-gallblader,dampness-heat-in-liver-and-spleen.(3)Dampness-heat-in-liver-and-gallblader and dampness-heat-with-blood -stagnation-in-liver-and-gallblader had a rise of ALT/AST which refered cell damage associated with dampness-heat. (4) TBil, DBil value heighten tip liver bilirubin metabolic disorders, this research TBil, DBil in dampness-heat-in-liver-and-gallblader syndrome and dampness-heat-with-blood-stagnation-in-liver-and-gallblader syndrome and dampness-heat-in-spleen-and-stomach.which refered liver damage degree associated with dampness-heat. (5) TP, ALB, ALP value are lower in normal reference value, may be in the early stages of the disease.