The Expression Of Skp2 And Ki67 In Cervical Carcinoma And Its Clinical Significance

Objective: To explore the expression of Skp2 and Ki67 in cervical intraepithelial neoplasia and cervix carcinoma and its clinical significance.Methods: The expression of Skp2 and Ki67 were assessed by immunohistochemistry (EliVision) in cervical specimens, including 60 cases of cervix carcinoma and 30 cases of cervical intraepithelial neoplasia (CIN) , and 60 cases of normal cervical epithelia. The expression changes of Skp2 and Ki67 protein in the formation of cervical intraepithelial neoplasia and cervix carcinoma and the relationship between the clinical features and pathological features were analyzed.Results: Positive rates of Skp2 and Ki67 in normal cervical epithelia, CIN and cervix carcinoma were13.3% ,66.7% ,71.7% and 16.7%, 56.7%, 83.3%, The expression of Skp2 protein in CINⅡgroup was significantly higher than that in CINⅠgroup and normal cont rol group ( P < 0. 05) ,the expression in CINⅢgroup was higher than CINⅡgroup ( P < 0. 05) , the invasive squamous cell carcino2mal of cervix was significantly higher than the CINⅢgroup ( P < 0. 05) ,there was no significant difference between the CINⅠgroup and the normal cont rol group ( P > 0. 05) . The exp ressions of Ki67 in CINⅠ～Ⅱ, chronic cervicitis and cervical cancer were positivelycorrelated with clinical stage and pathological grade of cervical cancer ( P < 0. 05).respectively; positive rates of both in CIN and cervix carcinoma were notably higher than in the normal cervical epithelia ( P < 0. 01); in the same cervical carcinoma tissues(P < 0. 05)。Conclusion:Skp2 and Ki67 expression may play an important role in the development and progression of cervical carcinoma; Skp2 and Ki67 could be used as markers for early diagnosis of cervix carcinoma. It can be helpful for increasing the ratio of early diagnosis of cervix carcinoma.