Effect Of Terazosin On Drug Concentration Of Levofloxacin In Rat's Bacterial Prostatitis Tissue And Plasma

AIM To investigate the effect of terazosin on the distribution of levofloxacin in the rat's bacterial prostatitis tissue and plasma.METHOD 96 male SD rats were used to set up the model of acute bacterial prostatitis.,which were equally randomized into two groups: the only levofloxacin orally administered group and the combined terazosin and levofloxacin administered group. Six rats were sacrificed to collect their plasma and prostates to make tissue homogenate at each time point: 0.125 ,0.25 , 0.5 ,1 ,2 ,4 ,8 ,12 h after drug administration. The prostatic and plasma levofloxacin concentrations were detected by HPLC, and pharmacokinetic parameters were calculated by the 3p97 software program.RESULT There isn't significant difference about the concentration of levofloxacin in plasma between experimental group and control group,but there is significant difference in prostate.CONCLUSION Terazosin can elevate the concentration of levofloxacin in the rat's prostatitis tissue, but not in the plasma.