Study Of Association Between Serum Complement C3 And Metabolic Syndrome And Its Components In Women With Polycystic Ovary Syndrome

Objective To investigate the association between serum complement C3 (C3) and metabolic syndrome (MS) and its components in women with polycystic ovary syndrome (PCOS).Methods 91 women with PCOS and 115 age-matched normal women were enrolled in this study. Anthropometric measurements and biochemical parameters were evaluated to find the relationship between C3 and other parameters.Results The concentration of C3 was significantly higher in women with PCOS compared with control subjects((1.39±0.33vs 1.10±0.22g/L ,P <0.05);it was also higher in subjects with MS or anyone components of MS in PCOS;and the C3 level rose gradually along with the increase of the number of MS features (P <0.05). Correlation analyses indicated that the C3 was associated positively with waist circumference(WC), systolic blood pressur(eSBP), fasting blood glucos(eFPG), triglyceride(sTG), HDL-c(p <0.05)after controlling for age, total cholesterol (TC),LDL-c, fasting insulin (FINS),M value. Multiple linear regression showed WC and TG(β=0.31,P <0.05),TG(β=0.23,P <0.05) were significant influential factors to C3. Binary logistic regression analysis showed that subjects in PCOS group were more likely to get MS when C3 increase(P <0.05)Conclusion The concentration of C3 was a risk factor to MS in women with PCOS .