The Changes Of Plasma Leptin In Renal Transplantation Patients And Its Correlation With Bone Mineral Density

Objective:To investigate the plasma leptin levels in uremic patients before and after renal transplantation and the relationship between leptin and bone mineral density in parients more than one year after renal transplantation.Methods:222 patients enrolled in our study between March 2010 and March 2011 were classified into different groups to compare the plasma leptin levels according to time of kidney transplantation. At the same time, patients of kidney transplantation for more than one year were divided into three groups:normal bone mass, osteopenia and osteoporosis, in which the correlation between leptin levels and bone mineral density were analyzed. All data were analyzed using statistical software SPSS16.0.Results:There was no statistically significant difference among groups in respect to age, body mass index (BMI), blood glucose,serum calcium, blood lipids, serum creatinine and immunosuppressive regimen (p>0.05).With the recovery of renal function, plasma leptin levels gradually decreased to normal. The plasma leptin level in uremic patients is significantly higher than that in normal control group((p< 0.05).And no significant differences were found in groups of 6 months,1 year and 2 year while difference was significant in long-term group when compared to the control group(p<0.05). The plasma leptin levels were significantly lower in osteoporosis group and osteopenia group than that in normal bone mass group (p<0.05).Pearson correlation analysis showed that plasma leptin levels and bone mineral density had a positive correlation. The proportion of male patients is significantly higher than female in the abnormal bone mass group while compared to the control group (P<0.05)ConclusionrAs the renal function recovered in renal transplant recipients, plasma leptin levels gradually decreased to normal, but in long-term transplant group, the level of leptin increased again even with normal graft function. There was a positive correlation between Leptin and bone mineral density in patients who accepted renal transplantation more than one year. Male recipients had higher incidence of abnormal bone mass than female.