Biologica, Clinical And Hematologic Characteristics Of A Rare Acture Myeloegakaryoctic Leukemia

【Objective】The aim of this study is to analyze the biological, clinical and hematologicCharacteristics of a rare acute myelomegakaryocytic leukemia.【Methods】Three patients diagnosed with acute myelomegakaryocytic leukemia in hospitalaffilited Shantou university medical college between 2008 and 2011 and sevenpatients also diagnosed with acute myelomegakaryocytic leukemia in litereturereported were selected to as our research object. We analyzed the clinical signsand results of peripheral blood, bone marrow cell morphology, cytochemical stains,immunocytochemical stains, immunophenotype, chromosome karyotype and fusion geneamplification as to a comprehensive study of biological , clinical andhematological features of this disease.【Results】Ten patients diagnosed with acute myelomegakaryocytic leukemia were two typesof leukemia cells in bone marrow, one type leukemia cells were myeloblasts withpositive peroxidase (POX) stain and the expression of antigens CD13, and CD33；another were megakaryoblasts with negative POX stain and the expression of antigensCD36, CD41, CD42a and CD61. Three of ten patients(case 2, case 9 and case 10) withchromosome karyotype was t(9;22)(q34;q11). Among three patients with RT-PCR, twopatients(case 2 and case 3) showed positive BCR-ABL fusion gene amplification,three patients(case 1, case 2 and case 3) showed negative OTT-MAL fusion geneamplification.【Conclusion】(1) acute myelomegakaryocytic leukemia is existent and rare.(2) acute myelomegakaryocytic leukemia is most common in males, uncommon in females. Differenent ages are visible. White blood cells count in Peripheral blood are oftenhigh, but platelet count is often low. Myeloblasts and megakaryoblasts are easilyvisible in Peripheral blood. Live, spleen, and lymph node enlarged are common.(3) Ph chromosome and the BCR-ABL fusion gene are most common abnormalities ofgenetics and molecular biology of acute myelomegakaryocytic leukemia. Thisabnormalities are often poor prognosis.