The Image And Curve Analysis Of The Edge Flow And Hemodynamic Numerical Simulation Of The Cerebral Contex Ateriole Atherosclerotic And Its Significance

Background:Atherosclerosis is the chief culprit of cardio-cerebrovascular disease。In recent years, atherosclerosis has always been the hot spot of domestic and foreign scholars. A variety of hypothesis about the causes of atherosclerosis including: "damage response hypothesis, inflammatory reaction hypothesis", etc. Professor MingHua Zhuang research many years proposed and proved " the edge flow protective barrier " hypothesis。The base of this hypothesis is when him in research about the compatriots of the cerebral cortex of China children found the phenomenon of the endothelial of the cerebral cortex of China children is uneven: human was born with a bumpy vascular endothelium of the cerebral cortex microvascular which is the morphology base of cerebrovascular disease,and in physiological condition, the edge flow were to be the protective barrier and made a"physiologic smooth state"for the endothelial,and in order to maintain the normal flow of blood, if this a barrier to change for some factors is destroyed, may cause cerebrovascular disease.This topic is for further study of " the edge flow protective barrier "about the hemodynamic changes in intracranial atherosclerosis and discusses the relationship of cortex atherosclerosis and the edge flow protective barrier and hemodynamic and to perfect the hypothesis.Objectives:1. To clarfy the action of the edge flow protective barrier in cerebrovascular disease pathogenesis mechanism2.To perfect the pathogenesis of cerebral cortex atherosclerosis by use the Computer simulation of the hemodynamic of atherosclerosis and get the wall shear stress distribution of microvascular . Methods:1 .Measured the data which numerical simulation need by animal experiments .2.Numerical simulation: first use gambit software build normal blood essels and narrow vascular model, second use the fluent software for computer simulation of hemodynamic behavior. Draw the velocity distribution,the thickness of the edge flow, the speed of the edge flow, shear stress images and data etc.Results:1. The blood flow performance laminar in normal essels. In the narrow vascular the laminar flow disrupted especially 96% narrow vessels.And in the bifurcate the flow velocity was more slow.2.In normal vessels the shear stress less than 1dyn/cm2,and the image of shear stress is a straight line no fluctuations expect on the pot of bifurcate place.In narrow vascular the the shear stress less than 1dyn/cm2 also but significant fluctuations on the pot of the junction. On the pot of bifurcate place also fluctuations.3. In the narrow vessel the edge flow more thinner than in normal vessel.4. In the narrow vessel the velocity of edge flow was more slow than in normal vessel.Conclusion:1. Numerical simulation accorded with animal experiment results, confirmed the correctness of animal experiments.2. Numerical simulation confirm The edge flow protective barrier.3. Numerical simulation for the wall shear stress calculated microvascular low shear stress, and in a narrow vascular shear stress and normal blood vessels bifurcate department shear stress has obvious concussion. For cerebral cortex atherosclerosis blood flow protective barrier theory, margins provided the basis of hemodynamic changes.