Study On Releasemechanism In Vitro Of Compound Danshen Sustained-release Tablets

Objective: Different methods were used to evaluate release release machanism in vitro about balance-release compound Danshen sustained release tablet ,providing scientific basis for the research and development of sustained-release preparation of the traditional Chinese medicine . Methods: HPLC method,GC-MS method and dissolution test were used to determine the accumulated release rate of water-soluble target ingredients salvianolic acid B,ginsenoside Rg1 and liposoluble target ingredients Tanshinone IIA,Borneol .The cumulative curve of drug release data was fitted to zero o rder, f irst-order,Higuchi and Korsmeyer–Peppas release model to ascertain the kinetic, Scanning electron microscopy method,Texture analyzer instrument method and Stereo micro-scope method was also applied to evaluate the release process in vitro of compound Danshen sustained-release tablet synthetically. Results: Target ingredients of compound danshen sustained-release tablet had a similar release behavior and corresponded Higuchi and Korsmeyer–Peppas release model. Release machanism was concurrent action of diffusion and erode, which is closely related to gel thickness changes. Conclusion: Scanning electron microscopy method,Texture analyzer instrument method and Stereo microscope method is simple and practicality,which could be used to evaluate Release machanism of compound danshen sustained-release tablet.