System Desing And Simulation Study Of Intraperitoneal Hyperthermic Chemotherapy (Hipec) Machine

Introperative peritoneal hyperthermia chemotherapy (HIPEC or IPEC) using interaction of regional high-dose chemotherapy and hyperthermia can induce apoptosis and necrosis of intraoperative tumor cells. Its positive clinical effect has been confirmed by many researchers and doctors around the world. However, current HIPEC machines have low control accuracy and the therapeutic efficacy is not ideal. Therefore, development of an improved version of HIPEC machine has a positive and practical significance. This work is supported by the Shanghai Jiao Tong University Interdisciplinary Fund in Medicine (Science) & Engineering (YG2009MS15), and it mainly focuses on the system design of HIPEC machine. In order to have a satisfactory therapeutic performance, parameters of the designed control system have been optimized, and numerical simulation of intraoperativel abdominal cavity has been done. The primary results of the thesis are summarized as follows.System scheme of HIPEC machine is proposed, which consists of temperature control system based on TMS320F2812, integrated chemotherapy liquid circulatory system based on peristaltic pump and real-time temperature monitoring HCI system. Selection of Pt100 RTD and peristaltic pump and principle of circulatory system is elaborated. F2812, the control core of hardware system, works with TRIAC plate heater drive circuit to collect and feedback temperature signals. To satisfy the requirements of EMC design for medical equipment, special anti-interference design is added.In MATLAB environment, PC program completes the temperature drawing and monitoring functions. DSP program completes the functions of system initialization, signal acquisition and transmission, and control output. Typical PID control algorithm is used. Flow charts of 3 stages of operation, which include heating, chemotherapy and callback, are also given.Temperature control experiments were carried out on the experimental platform. Several rounds of experiments based on PID algorithm were performed. Seven sets of experimental data were analyzed and optimal control parameters were achieved.Since temperature homogeneity in closed-abdomen HIPEC can`t be ensured by stirring like open technique. Computational Fluid Dynamics (CFD) simulation of intraperitoneal temperature field and velocity vector field was calculated by FLUENT adopting standard k-εturbulence model. Through numerical simulation on three kinds of intraperitoneal piping methods, it shows that the method of three inflows and two outflows with closed abdomen is sufficient for treatment. Relevant 3D intraperitoneal temperature field analysis was also given.