| Objective:To probe into expression of CRD-BP and its clinical significance in human rectal carcinomas.Methods:The expression of c-myc and CRD-BP are detected by immunohistochemistry, using the SP staining method at 60 rectal carcinomas tissues,20 paraneoplastic tissues and 20 rectal adenoma with atypical hyperplasia tissues. The data is analyzed with clinicopathologic parameters by principle of statistics.Results:The positive rate of c-myc in rectal carcinomas tissues, rectal adenoma tissues and paraneoplastic tissues were 68.33%(41/60),35%(7/20) and 5%(1/20),respectively. The positive rate of c-myc in rectal carcinomas tissues was significant higher than those in rectal adenoma tissues and paraneoplastic tissues(χ2 were 6.944 and 24.127, respectively; P were 0.008 and 0.000, respectively). The positive rate of c-myc in rectal adenoma tissues was significant higher than those in paraneoplastic tissues(χ2 was 3.906 P was 0.048). c-myc expression in rectal carcinomas tissues was significantly correlated with metastasis of lymph and metastasis(all P< 0.05), but not correlated with gender, age, tumorous location, tumorous morphology, histology grade, CEA level before surgery and Dukes stage (all P> 0.05).The positive rate of CRD-BP in rectal carcinomas tissues, rectal adenoma tissues and paraneoplastic tissues were 60%(36/60),25%(5/20)and 0%(0/20), respectively. The positive rate of CRD-BP in rectal carcinomas tissues was significant higher than those in rectal adenoma tissues and paraneoplastic tissues(χ2 were 7.355 and 21.818, respectively; P were 0.007 and 0.000, respectively). The positive rate of CRD-BP in rectal adenoma tissues was significant higher than those in paraneoplastic tissues(χ2 was 5.714, P was 0.017). CRD-BP expression in rectal carcinomas tissues was significantly correlated with Dukes stage, metastasis of lymph and metastasis(all P< 0.05), but not correlated with gender, age, tumorous location, tumorous morphology, CEA level before surgery and histology grade (all P>0.05).The expression of CRD-BP is positively correlated with c-myc (r=0.395, p<0.01), Dukes stage(r=0.368, p<0.01), metastasis of lymph (r=0.319, p<0.05) and metastasis (r=0.268, p<0.05). The expression of c-myc is positively correlated with metastasis of lymph (r=0.336, p<0.01) and metastasis (r=0.369, p<0.01). Conclusions:(1). The Positive rates of c-myc are Progressively higher from paraneoplastic tissues to rectal adenoma tissues and rectal carcinomas tissues, suggesting that c-myc plays a significant role in the occurrence and development of rectal adenoma. The expression of c-myc is significantly higher in the rectal carcinomas tissues which have metastasis of lymph than those no metastasis of lymph, higher in the rectal carcinomas tissues which have metastasis than those no metastasis. The expression of c-myc is positively correlated with metastasis of lymph and metastasis, indicating that c-myc is involved in the tumor invasion and formation of metastasis.(2). The Positive rates of CRD-BP are Progressively higher from paraneoplastic tissues to rectal adenoma tissues and rectal carcinomas tissues, suggesting that CRD-BP plays a significant role in the occurrence and development of rectal adenoma. The expression of CRD-BP is signifieantly higher in the tissues of Dukes stage C+D of rectal carcinomas than those in Dukes stage A+B, higher in the rectal carcinomas tissues which have metastasis of lymph than those no metastasis of lymph, higher in the rectal carcinomas tissues which have metastasis than those no metastasis. The expression of CRD-BP is positively correlated with Dukes stage,metastasis of lymph and metastasis, indicating that CRD-BP is involved in the tumor invasion and formation of metastasis.(3). The expression of CRD-BP is positively correlated with that of c-myc, indicating that c-myc and CRD-BP play congenerous roles in the occurrence, development and metastasis of human rectal carcinomas. CRD-BP may be a potential target for targeted therapies of rectal carcinomas. |
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