Correlation Between Soluble E- Selectin,interleukin-10 And The Degree Of Coronary Artery Lesions In Acute Coronary Syndrome

Background: Acute coronary syndrome (ACS) is a group of serious cardiovascular diseases, including unstable angina(UA), non-ST segment elevation myocardial infartion(NSTEMI),ST-segment elevation myocardial infartion(STEMI) and sudden death. Atherosclerotic plaques unstable,rupture,resultant platelet aggregation and thrombus formation causing acute coronary artery obstruction or coronary artery luminal stenosis increased dramatically is believed to be responsible for most of the development. In the process, inflammation is the most important initiating factor. Both inflammatory factors and anti-inflammatory factors are joining in the pathophysiological process. Recently, it has been demonstrated that the serum levels of soluble E-selectin(SES) in ACS patients are significantly higher than those in normal patients, and the serum levels of soluble Interleukin-10(IL-10) are also significant changed in ACS patients. It is prompted that the serum levels of inflammatory factor SES and anti-inflammatory factor IL-10 might correlated with the development of coronary heart disease(CHD) and the instability of plaque, it migh be a sensitive marker to predict the outcome of CHD.Objective: To observe the variations of SES,IL-10 and hs-CRP levels in the different types of coronary heart disease patients; To analyze the correlations between the SES,IL-10,hs-CRP levels with the degree of coronary artery stenosis in CHD patients; To explore its effects on the development of CHD and the mechanism of incidence acute effection; To discussion the values of its variation to regarde the plaque stabilitiy and to predict the outcome of CHD patients. Materials and Methods: Total 94 patients who were suspected suffering from CHD and received coronary angiography(CAG) were selected for the study. 32 patients with normal CAG as controls; 62 patients had angiographic stenosis of coronary arteries, including 23 patients with SAP, 39 patients with ACS. Serum SES,IL-10 level was determined by ELISA and the stenosis with≥25% diameter reduction were assessed according to angiographic coronary stenosis morphology.Results:(1)The serum levels of SES in ACS group(2.11±0.13ng/ml) were significantly higher than those in SAP group and control group(1.37±0.16,1.42±0.14 ng/ml)(all P<0.01), which were similar in SAP group and control group(P>0.05); the serum levels of IL-10 in ACS group(402.87±19.21pg/ml) were higher than those in SAP group and control group(330.52±25.01,300.47±21.20 pg/ml)(P<0.05, P<0.01); The serum levels of hs-CRP were highest in ACS group(773.33±50.49ug/dl)(all p<0.01); The serum levels of SES,IL-10,hs-CRP were similar among SAP and control groups(P>0.05);(2)The serum levels of SES had statistical relationship with hs-CRP levels (P<0.05,r=0.260); The serum levels of IL-10 had no statistical relationship with hs-CRP level(sP>0.05,r=0.098); (3) There were no statistical relationship in SES,IL-10 and hs-CRP levels with the count of coronary artrey stenosis (r = 0.093,-0.026,0.056) (all P>0.05)and the degree of coronary artery stenosis(r = 0.043,-0.077,0.051)(all P>0.05).Conclusions: (1) The serum levels of SES,IL-10 were significantly elevated in ACS. It exposed they may reflected the intability of atherosclerotic plaques ; The serum levels of SES and IL-10 may be a valuable target to predict unstable plaques as well as coronary heart risk;(2)They cannot reflected the degree of coronary artery stenosis .