| OBJECTIVEThe effect of neoadjuvant chemotherapy for locally advanced cervical cancer and the time that the method markedly worked are systematically evaluated.METHODSSearches of MEDLINE (1982-2009.4), EMBASE (1982-2009.4), CBM (1982-2009.4), CNKI (1982-2009.4), VIP (1982-2009.4), Wang Fang (1982-2009.4) and hand-searches 5 journals of obstetrics and gynecology (Chinese Journal of Obstetrics and Gynecology, Chinese Journal of Practical Gynecology and Obstetrics, Gynecology and practical magazine, reproductive and contraceptive, the progress of modern gynecology) and references of included literature. Select trials based on including and excluding criteria, assess quality of literature, extract data and Meta-analysis with Revman5.0 and cumulatively Meta-analysis by Stata 9.0.RERULTSRadiotherapy after neoadjuvant chemotherpy can improve overall survival in patients of cervical cancer compared with radiotherapy alone (P=0.008<0.05,95%CI=[0.52,0.90]). Cumulatively Meta-analysis showes that this trend has already started since 1998. Surgery after neoadjuvant chemotherpy can improve overall survival in patients of cervical cancer compared with radiotherapy alone (P=<0.00001,95%CI=[0.32,0.63]) Cumulatively Meta-analysis showes that this trend has already started since 1996. Surgery after neoadjuvant chemotherpy can improve overall survival in patients of cervical cancer compared with surgery alone (P=0.003<0.05, 95%CI=[0.43,0.85]). Cumulatively Meta-analysis showes that this trend has already started since 1998.CONCLUTIONNeoadjuvant chemotherapy for locally advanced cervical cancer, regardless of their combination with the use of radiotherapy or surgery, is effective. There is evidence to support the conclusion 10 years ago.
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