An FMRI Study Of Hands Active Or Passive Movement In Healthy Adult Subjects

Objective:To assess differences in brain activations between right hand active movement and passive movement using block design functional MRI(fMRI). Methods:Nine adult right handedness healthy volunteers were studied. fMRI was performed with two different paradigms,namely, active fingers opposition movement and passive fingers opposition movement. fMRI data were analyzed using SPM5,and the results were demonstrated using xjview8.0.Results:Right hand movement both actively and passively produced significant activation in contralateral sensorimotor cortex(SMC),contralateral premotor cortex(PMC),bilateral supplementary motor area(SMA)and ipsilateral cerebellum. The tendency that the actived brain area center in the contralateral SMC and PMClocated more forward during active movement than during passive movement was present and the contralateral SMC was the greatest and the most frequently actived brain area. The contralateral posterior parietal cortex (PPC) was less relevant to the hand movement either actively or passively. Compared with active movement, the passive movement actived more areas in posterior central gyrus than in anterior central gyrus. Conclusion:The study proved that both active and passive movement led to significant activation in the brain areas which are responsible for hand movement, but there are some differences in the locations of the actived cortex areas and the incidence of the activated cortex areas except the contralateral SMC. Objective:To assess differences in brain activations between affected hand active movement and passive movement using block design functional MRI(fMRI). Methods:12 ischeamic stroke patients were studied. fMRI was performed with two different paradigms,namely, active fingers opposition movement and passive fingers opposition movement. fMRI data were analyzed using SPM5,and the results were demonstrated using xjview8.0.The chance of the actived brain areas were countered, including both contralateral and ipsilateral side of the SMC,PMC,SMA,PPC,and cerebellum,the volumes of the actived brain areas were observed too. Results:the affected hand movement both actively and passively produced significant activation in bilateral sensorimotor cortex(SMC),premotor cortex(PMC)supplementary motor area(SMA) and cerebellum. The tendency that the volume of the actived brain area in the contralateral SMC were larger than the volume of the actived brain area in the ipsilateral SMC was present and the contralateral SMC was the greatest and the most frequently actived brain area. The posterior parietal cortex (PPC) in both hemispher were less relevant to the hand movement either actively or passively. The cerebellum was less actived during active and passive movement,moreover the actived incidence in contralateral and ipsilateral cerebellum was similar. Conclusion:The study proved that both active and passive movement led to significant activation in the "classical" motor network after stroke. In a word,fMRI of active and passive movement may illustrate the functional substrate of the therapeutically beneficial effect of physicaltherapy(PT) in brain function reorganization.