Evaluating The Cardiac Function With Velocity Vector Imaging In Patients Undergone Percutaneous Coronary Intervention

Object:To assess the regional and global function in patients with coronary artery disease (CAD) who have undergone percutaneous coronary intervention (PCI) using velocity vector imaging (VVI).Methods:20 CAD patients without myocardial infarction who undergone PCI (PCI group)and 20 healthy subjects(control group) confirmed by Coronary angiography (CAG) were included. The patients of PCI group were followed up by the time of pre-PCI, post-PCI and 3 months after PCI. The long axis views of apical 4-chamber,3-chamber,2-chamber of left ventricle and short axis views at the level of mitral valve, papillary muscle and apex were acquired with Siemens Sequoia 512 ultrasound system. The longitudinal, radial, circumferential motion and ventricle rotation and torsion were analyzed with the off-line syngo US workplace software.Results:1. Parameters of longitudinal, radial and circumferential wall motion and deformation show significant differences between ischemic segments and normal control segments such as Longitudinal displacement (cm) (endo:4.22±2.78 vs.5.64±2.96, P=0.00; epi:3.34±2.74 vs.4.08±2.96, P=0.00), Radial Velocity (A) (cm/s) (-1.23±1.07 vs.-1.52±1.22, P=0.00), Radial peak systolic Strain Rate (S)(s-1) (1.42±0.86 vs.1.70±1.02, P=0.00), Radial peak late-diastolic Strain Rate (A) (s-1) (-0.85±0.70 vs.-1.00±1.01, P=0.01) and Radial peak systolic Strain(%) (21.65±15.42 vs.40.84±12.24, P=0.00). Left ventricular torsion degree obviously decreased in patients with coronary heart disease compared with that of the control group, while ejection fraction showed no significant difference between the 2 groups.2. Radial peak systolic Strain was improved shortly after PCI, while Longitudinal Displacement, Radial Velocity (A), Radial Strain Rate (S), Radial Strain Rate (A) were improved 3 months later. Ventricle torsion showed no significant change during the follow up. Conclusions:1. The segmental motion and deformation function was demaged in ischemic segments compared with that of the normal control segments. VVI can quantify the abnormality of regional and global function in the ischemic segments which can not be found in the routine echocardiography. It is a useful tool for assessing the myocardial regional function.2. Radial strain sensitively reflects the early improvement of cardiac motion and deformation function after PCI; Longitudinal displacement, Radial Velocity (A), Radial Strain Rate (S), Radial Strain Rate (A), circumferential strain were improved later. The results confirmed the effect of PCI on myocardial function, which can be evaluated quantitatively by VVI.