| This paper described two aspects of theory and clinical observation of the Soviet Union through the seed oil soft capsule hyperlipidemia (phlegm deter card) patients before and after the safety index:alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (Bun), creatinine (Cr); and outcome measures of total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C) changes, further assessment of the Soviet Union seed oil soft capsule on blood lipid regulation of safety and efficacy, thereby of "Qi and Phlegm, Jiangzhitongmai" law on the treatment of hyperlipemia and its mechanism.Theoretical research:Perilla is a commonly used traditional Chinese medicine, with lower gas phlegm, intestines and other effects. In recent years, according to a number of studies reported in the literature and found that perilla seed oil as high as 30-50% fatty oil contains 90% unsaturated fatty acids (such as linolenic acid, linoleic acid, oleic acid, etc.). Pharmacological test results also showed that Perilla seed oil has significant lipid-lowering, antithrombotic, antitumor and other effects, great development value. Perilla oil soft capsule is loved by the Fuzhou Pharmaceutical Co., Ltd. and Jiangsu Jiangshan Pharmaceutical Co., Ltd. to jointly develop Chinese medicine Category 5 drugs, with Qi and Phlegm, Jiangzhitongmai the effect, several clinical trials to prove their use hold the spit in the treatment of hyperlipidemia was significantly curb card effects.Clinical Research:Objective:The treatment and control group comparison study, objective assessment of Qi and Phlegm, treatment of hyperlipidemia Jiangzhitongmaifang the efficacy and safety. Methods:Simple randomized, controlled clinical trial principles, selected 50 cases consistent with the diagnosis of combined hyperlipidemia, and TCM standards consistent with phlegm deter patients 50 patients were divided into two groups, with perilla oil soft treatment group 25 cases; Western control group,25 cases with statin drug treatment. A course of 4 weeks.Results:The efficacy of serum lipids compared:group comparison:treatment group TC, HDL-C was statistically significant (P<0.05), TG are statistically significant (P<0.01), LDL-C before and after treatment was not statistically significance (P> 0.05), the control group before and after treatment TG, LDL-C and HDL-C was statistically significant (P<0.05), TC was not significant (P> 0.05); four indicators between the two groups before treatment There was no statistical significance (P> 0.05), TG after treatment was statistically significant (P<0.05), TC, LDL-C and HDL-C were not statistically significant (P> 0.05). Second group of security indicators (ALT, AST, Bun, Cr) comparison:before and after treatment ALT, AST, Bun, Cr (P> 0.05) were not statistically significant, the control group before and after treatment ALT (P<0.05) was statistically significance, Bun, Cr, AST (P> 0.05) were not significant. Between the two groups before and after treatment ALT, AST, Bun, Cr (P> 0.05) were not statistically significant.Conclusion:"Qi and Phlegm, Jiangzhitongmai" method, with perilla seed oil soft capsule on hyperlipidemia in the regulation of triglyceride, total cholesterol, and achieved good effect, and no effect on the liver and kidney function, with good security, perilla seed oil soft capsule can be used with mild to moderate hypertriglyceridemia in patients with elevated total cholesterol, should be further to expand its use in clinical research to explore. |
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