Clinical Study Of Treatment To Mid-advanced Colorectal Cancer Use Prescription Of Strengthen Spleen, Dredging Stagnation And Removing Toxic Combined With Oxaliplatin-based Regimen

Objective:To chemotherapy-based treatment, " strengthen the Spleen and reinforce Qi and Dredging stagnation and removing evil prescription " in the main line, observe strengthen the Spleen to reinforcing Qi and Dredging stagnation and removing evil prescription's treatment effects and to explore its mechanismMethods:The diagnostic criteria of Western medicine, Chinese medicine syndrome differentiation standards, clinical efficacy evaluation criteria, with reference to the Medical Secretary, Ministry of Health of People's Republic of China, the relevant standard-setting in standardization of the diagnosis and treatment of common malignant tumors of China and The Guiding Principles of Clinical Study of Chinese Medicine. Choose 40 patients with colorectal cancer, and divide them randomly into treatment group and the control group. Take strengthen the Spleen to reinforcing Qi and Dredging stagnation and removing evil prescription for the treatment group(20 cases),one bag one day, and even served six weeks, and combined with oxaliplatin + CF/5-FU orXELOX chemotherapy, the specific drug as follows:oxaliplatin cisplatin 130mg/m2 ivgtt2h dl; calcium folinate 200mg/m2 ivgtt2h d1-5; 5-FU 300mg/m2 ivgtt4h d1-5. Every 3 weeks one cycle; or oxaliplatin cisplatin 85g/m2 ivgtt2h d1,8; xeloda85mg/m2,were taken orally forl4days,interval 7 days,Every 3 weeks one cycle;the control group,20 cases, only for oxaliplatin chemotherapy + CF/5-FU or XELOX program 2 cycles after treatment, compared Chinese clinical symptom, living condition before and after treatment, tumor symbols in serum and side effect after chemotherapy between 2 groups.Results:The treatment group has the obvious advantages:improving the clinical symptoms of patients with colorectal cancer, the quality of life,The treatment group displayed more effeeive in all eviating the side effects(P<0.05), such as abdominal pain,hematochezia,vomitting and back pain. aversion cold. however, in reducing the value of serum CEA have no significant difference (P<0.05), compared to the chemotherapy alone group,. especially in reducing nausea and vomiting has obvious advantages,the side effects were no significant difference.Conclusion:The usage of involving oxaliplatin chemotherapy in the treatment of advanced colorectal cancer with strengthen the Spleen and reinforce Qi and dredging stagnation and removing evil prescription; it improves patients'clinical symptoms and living conditions, reduces the side effects of chemotherapy. The treatment methods of strengthen the Spleen to reinforce Qi and dredging stagnation and removing evil prescription; are one of the effective ways to treat colorectal cancer.