Study Of The Relationship Between 3-deoxyglucosone And Diabetic Microvascular Complications

Object:Observation, analysis in state of type 2 diabetes(T2DM) under serum 3-deoxyglucosone(3-DG) level and the relationship between chronic microvascular complications of diabetes. Observed the influence of Effective traditional Chinese medicine to diabetic retinopathy(DR) on the level of serum 3-DG, explore the relationship between the level of serum 3-DG and symptoms improved of DR.Methods:1. Studied 106 T2DM patients who were referred to endocrinology Department of Chinese medicine hospital in Suzhou. Observed the serum 3-DG levels, blood glucose, diabetes duration, retinopathy symptoms and UmAlb/UCr. Analysis of the serum 3-DG levels, blood glucose, diabetes duration, retinopathy symptoms, UmAlb/UCr, Diabetic Nephropathy(DN), the relationship between the total microvascular complications. Blood glucose, serum 3-DG levels were tested before and after the treatment, analysis of the interaction between them.2. Studied 48 DR patients who referred to endocrinology department of Chinese medicine hospital in Suzhou. Control of blood glucose, blood pressure level into the standard range, Randomized to treatment for all three months of YiQiYangYinHouXue Decoction and Pancreatic Kininogenase, serum 3-DG levels and retinopathy symptoms were tested before and after the treatment, analysis of changes before and after treatment the interaction between them.Results:1. Blood glucose, serum 3-DG levels were significantly higher when chronic diabetes microangiopathy happened, and the diabetes duration was extended. The incidence of DR,DN and the total microvascular complications were significantly higher when HbAlc=7%, diabetes duration was more than 5 years and the serum 3-DG level was higher than 200(ng/ml).2. The level of serum 3-DG and diabetes duration had no significant correlation, but the level of serum 3-DG was clearly linked to the blood glucose (P<0.05).The serum 3-DG level and blood glucose decreased significantly after lower blood glucose treatment (P<0.05), But the decline in the difference before and after treatment between the two was no correlation.3. Eyesight and retinopathy symptoms are better after treatment by Chinese medicine, meanwhile eyeground hemorrhage and ocular manifestation improved significantly (P<0.05).The level of serum 3-DG decreased significantly in treatment group and control group (P<0.05),the decrease in treatment group(63.93%)was better than control group(35.30%). Retinopathy symptoms were improved while the level of serum 3-DG was also decreasedConclusion:In addition to blood glucose, other than diabetes duration, the level of serum 3-DG was another independent risk factor for chronic microvascular complications of diabetes, there may be a interaction between Serum 3-DG levels and the improvement of diabetic retinopathy.The level of serum 3-DG may also be regulation of blood glucose and 3-DG metabolic enzyme system, but it had no direct relationship with diabetes duration.