| The Functional Dyspepsia is a clinical common disease and frequently-occurring disease,almost everyone of us have occurded these symptoms. At present a survey, because of dyspeptic symptoms of all internal medicine outpatient treatment accounted for about 30%, accounting for 70% of specialist out-patient to digest, and functional dyspepsia accounted for 30% digestion specialist out-patient 40%. Although the functional dyspepsia does not cause serious complications or threatening the lives of patients, but early satiety, upper abdominal pain, postprandial fullness discomfort and other symptoms in patients with a serious impact on the quality of life and constitute a very high medical costs. Therefore, finding an effective treatment of functional dyspepsia approach, which is the clinical and scientific research hot spots.At present, for the pathogenesis of functional dyspepsia has not been fully clarified, modern research has confirmed that interstitial cells of Cajal of the gastrointestinal tract as a "pacemaker" cells, involved in the formation and conduction of gastric electrical signals, and the occurrence of this disease is closely related to. Because of its performance in a variety of clinical symptoms, and easily accompanied with other symptoms, Western medicine to alleviate the symptoms. A number of prokinetic, such as domperidone, cisapride and so on, although can significantly alleviate the symptoms of functional dyspepsia.However, a limited role, and there is recurrence after withdrawal, side effects such as disrupting hormone secretion in vivo. Growing number of studies have shown that Chinese medicine not only for the regulation of gastrointestinal function have a good role,but also pay more attention to the overall regulation of the body.Tiaozhong granule is based on classic recipe Pinellia heart-draining decoction,and reference to many years of clinical experiences.Tiaozhong granule can adjustment of yin and yang, Acrid bitter drop, the effect of reinforcing and reducing carrot. The topics to be from clinical observation and experimental study to explore two aspects of particle transfer treatment of functional dyspepsia and the mechanism of action of the ICC expression. 1 Clinical observation of functional dyspepsia by Tiaozhong granuleObjective:To observe the tiaozhong granule on the clinical efficacy of functional dyspepsia.Methods:82 cases of patients with functional dyspepsia were randomly divided into treatment group (Tiaozhong granule group) 42 cases, the control group (Domperidone group) 40 cases. Use of standard treatment, record and observe the clinical efficacy, before and after the individual symptom scores, before and after the EGG dominant frequency and dominant power, before and after the traditional Chinese medicine to quantify the symptoms and different types of TCM efficient.Results:The treatment group than the control group markedly improved the clinical cure rate (P<0.01) and the total effective rate higher (P＜0.05), up 90.48 percent; treatment group the individual symptom score than the control group (P<0.05); treatment group in the Chinese integral and quantify the efficacy of different syndromes were significantly superior to the control group (P<0.01); treatment group in improving the EGG parameters and gastric electrical rhythm is superior to the control group (P<0.05), and no obvious adverse reactions, safety.Conclusion:Tiaozhong granule can treat functional dyspepsia safety and effectively.It is worth of clinical application and promotion of. 2 Research on Tiaozhong granule on the FD rat antral gastric electrical rhythm and the right distribution of interstitial cells of Cajal.Objective:Observe the transfer of particles to the FD, and antral gastric electric rhythm part of the distribution of interstitial cells of Cajal effects of animal experiments to determine the effectiveness of the drug.Methods:With SD rats as the experimental objects, using folders to copy France FD modeling tail model. In accordance with the principle of randomization, were divided into normal group, the model group, adjusting particle group, Pinellia heart-draining decoction group, domperidone group; given different drug treatment, by EGG equipment and immunohistochemical method to observe the rat gastric electrical parameters, and sinus rhythm between the distribution of interstitial cells of Cajal.Results:Treatment groups can improved to varying degrees of gastric electric rhythm disorders and parameters. Compared with model group, there are differences (P<0.05, P<0.01):in the EGG dominant frequency, the transfer of particles is superior to Pinellia heart-draining decoction and domperidone (P <0.05); in the EGG dominant power, the Transfer of particles is superior to Pinellia heart-draining decoction and domperidone (P<0.05).The antral part of the treatment group, the distribution of interstitial cells of Cajal with model group, group differences were statistically significant (P<0.01), adjusted particles is superior to Pinellia heart-draining decoction (P<0.05), adjusted particles is superior to domperidone (P<0.01).Conclusion:Tiaozhong granule to improve the FD rat gastric electric rhythm disorder and improve the electrical parameters of the stomach and improve gastric antrum between the expression of interstitial cells of Cajal are superior to Pinellia heart-draining decoction and domperidone. |
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