The Analysis Of Birth Defects Monitoring And The Investigation Of Its Risk Factor In Hengyang

Objective: To Understand the situation of birth defect in Hengyang during 2002—2008 years, furthermore to explore the possible influence factores of congenital limb deformity, and evaluate the relative importance of each influence factor,then provide scientic guidelines for reducing the rate of congenital limb deformity.Methord: To collect the date of birth defects which occurred in Hengyang during the periord of 2002 to 2008 years, all live or still births with 28 weeks of gestation or more were assesed within 7 days after delivery. And then calculate, compareand analyse the relationship between the incidence rate of perinatals, BD. A 1:2 matched case control study was designed, in which each case was matched with two normal controls on the sex, living dirstrcts, and birth date before or after two weeks. By means of simple and multivarible conditional Logistic regression to discuss the date of each factors OR and their 95%CI.Result: During the seven years, about 177465 prenatal children and 1337 children with congential anomalies were monitored. The overall prevalence rates of birth defect has been increasing during the periord.Birth defect was accounted for an increasing proportion of perintal deaths in Hengyang, and has became one of the major causes of perinatal deaths. The prevalence of rate of congential anomaly were higher in boy than in girl. There is obviously difference in the rate of BD between rural areas and urben areas.The result found signifient rate in different materal age group. The largest number of congenital anomalies is cleft lip with or without cleft palate,and the second is polydactyl. Arranged with system parts, the first is limb deformity. The result of multivarible conditional Logistic regression found the illness and maternal occupational exposure during their first trimester pregnancy were significiantly associated with birth defect, and the same result also were found in the factors such as medication during pregnacy, hereditary history of BD, delivey history of BD and pregnacy adverse mental or emontional. Their OR and 95%CI were 15.63(2.99-81.7), 4(1.44—11.0), 6.73(1.29—34.9), 19.79(4.3—91), 10.18(1.51—68.5), 10.27(2.21—47.52), respectively. Eating fish, meat and egg during their pregnancy was protective factor, the OR and 95%CI of them was 0.10 and 0.01—0.87 respectively.Conclusion:1. The revalence rate of congenital anomalies has been increasing overally during the seven years in Hengyang.And arranged with,limb deformity has been the first .2. The prevalence of rate of congential anomaly were higher in boy than in girl.There is obviously difference in the rate of BD between rural areas and urben areas.The result found signifient rate in different materal age group.3. The most risk factor of limb deformity is catching illness during the first trimester pregnancy according to the OR,and followed by hereditary history of BD ,materal occupational exposure during pregnancy, delivery history of BD.Protictive factor is eating fish,meata and egg duringtheir pregnancy.