Changes Of Pulmonary Function In Patients With Type 2 Diabetes And Analysis Of Related Factors

Objective:To investigate the changes of pulmonary function in patients with type 2 diabetes and its related factors. Methods: 74 cases with type 2 diabetes patients(diabetes group) were selected according to pulmonary function test .Triglyceride, total cholesterol, C-reactive protein, homocysteine, lipoprotein-a, glycosylated hemoglobin (HbA1c), urine albumin excretion rate(AER),fundus examination and nerve conduction velocity, insulin resistance index were detected in 74 patients with type 2 diabetes.All cases were observed in nine months while 74 cases of nondiabetic as control subjects,two groups'pulmonary function were compared,related factors of type 2 diabetes were analyzed by multiple linear regression analysis.Results:Compared with the control group, vital capacity(VC),forced expiratory volume in first second(FEV1),total lung capacity(TLC),maximal voluntary ventilation(MVV),diffusion capacity for carbonmonoxide of lung(DLCO)and diffusion capacity for carbon monoxide per liter of alveolar volume(KCO)were significantly decrease in the type 2 diabetic group(P<0.05).Liner regression analysis showed that VC,FEV1,TLC,DLCO,KCO were negative correlated with HbA1c,VC was negative correlated with homocysteine.(P<0.05),maximal voluntary ventilation(MVV),DLCO,KCO were negative correlated with complication integra(P<0.05).DLCO was negative correlated with insulin resistance index(P<0.05). Conclusion:The patients of type 2 diabetes exist abnormal pulmonary ventilatory function and diffusive function,which imply that the lung might be the target organ in the chronic pathologic changes of diabetes.Glycemic control,ameliorating insulin tesistance and anti-oxidative stress therapy are the emphasis of the prevention and therapy .