Effect Of Interactions Between FTO Gene Variation And Lifestyle On Metabolic Syndrome

Objective: To study the Effect of interactions between the single nucleotide polymorphism of rs9939609(the genotypes and the frequency) in FTO(fat mass and obesity-related gene) and lifestyle on metabolic syndrome.Methods: Genotyping of FTO rs9939609 polymorphism was performed in 269 patients with metabolic syndrome and 263 controls using an allelic discrimination assay with TaqMan probes.The allele frequency distribution was computed and the various clinical metabolic parameters of different genotype groups were compared. Examination of gene-lifestyle interactions with MS was analyzed by Logistic regression.Results:①Genotype frequencies of TT, AT and AA were 76.32%, 21.99% and 1.69%, respectively. The distribution was in accordance with H ardy—W einberg equilibrium.②The frequency of the A allele carriers was significantly higher in the metabolic syndrome group than in the control group. The A-allele of rs9939609 significantly increased MS risk with an allelic odd ratio (OR) of 1.863 [OR=1.863, 95%CI (1.231~2.819),χ2=8.674, P=0.003].③People carrying the A allele had higher body mass index (BMI), waist circumstance (WC), 2 hours plasma glucose (2hPG) than people with the T allele in MS group, but have no significant differences in control group.④A common variant in the FTO gene was associated with MS through an effect on BMI. An interaction between the FTO rs9939609 genotype and lifestyle was not found.Conclusion: These results indicated that a allele polymorphism of rs9939609 site in FTO gene may be a risk factor for MS through an effect on BMI. People carrying the A allele had higher BMI, WC, 2hPG than people with the T allele in MS group. Examination of gene-lifestyle interactions may provide further insights into the role of FTO in the pathogenesis of human obesity and MS.