The Effect And Mechanism Of Polycylic Aromatic Hydrocarbons Exposure On The Capability Of Learning And Memory In Crowd

Objective: Observation the effect of Polycylic aromatic hydrocarbons on the monoamine neurotransmitters and capabillity of learning and memory in crowa, to explore the mechanism of Polycylic aromatic hydrocarbons exposure on the capability of learning and memory in crowd.Methods: 100 healthy adult male coke oven workers were selected from a coke plant of a state-owned steel enterprise, 100 controls were selected from the oxygen factory. Adoption by oneself design of unify of investigate questionnaire, investigate research object of general circumstance, cultural degree, smoke cigarette, alcohol, life habit of eat to roast and on, work age, work kind, occupation change history, the system disease of the nerve spirit and household history, aware of self symptom etc.Concentration of benzo[a]pyrene(B[a])P in the working environment was monitored by High Performance Liquid Chromatography(HPLC)with fluorescence as detector. The level of urinary 1-hydroxypyrene was determ ined by High Performance Liquid Chromatography ( HPLC ) with fluorescence as detector. Neurobehavioral core test battery (NCTB)recommended WHO was performed on investigate objectto test the neurobehavioral changes.The plasma noradrenaline(NE),adrenaline(A),dopamine(DA)and serotonni (5-HT)levels were measured by high performance liquid chromatography(HPLC)with electrochemical detection.Results:Two sets are balanced in the age, work age, alcohol, smoke , food and so on(P>0.05), the existence difference of the cultural degree(P<0.05).Pass inquisition questionnaire arriving contact will appear to sneeze more usually than the matched control in each system aware of self the symptom, throat pain, cough, appetite not good and rash,particularly the contact appear concentration energy or memory difficulty are seriouser than control in the past one years in the nervous system symptom(P<0.05).In the working environment of B[a]P Concentration in coke oven workers were significantly higher than controls(P<0.05).The urinary 1-OHP concentrations in coke oven workers were significantly higher than controls(P<0.05).Tension—Anxiet(T) and Fatigue—Inertia(F) of the the Profile of Mood States(POM S) in the coke oven workers were significantly higher than controls(P<0.05).Compared to the controls,the scores of the coke oven workers wer lower in the average simple reaction time,total digital span,the forward digital span,digit symbol,first right dotting,averag right dotting and average total dotting,and the differences showed statistical significance(P<0.05).The plasma NE,DA,5-HT levels in coke oven workers were significantly higher than controls(P<0.05),the plasma A level was no significant difference,and results of correlation analysis showed that positive correlation between the plasma NE,DA,5-HT levels and the urinary 1-OHP concentrationsConclusion: The PAHs expose could make crowd capability of learning and memory be damaged, this kind of injure possibility relevant of PAHs expose,and increase the crowd monoamine neurotransmitters...