The Relationship Between Plasma APELIN-12 Level And Hypertension,insulin Resistance Of Type2 Diabetes Mellitus Patients

Objective: To investigate the correlation of plasma apelin-12 level and hypertension,obesity,insulin resistance,inflammation.Methods: 31 T2DM patients, 37 T2DM complicated with hypertension patients and 25 healthy controls were studied. The plasma level of apelin-12,tumor necrosis factor-α(TNF-α),blood fat,glycosylated hemoglobin(HbA1c),fasting plasma glucose,fasting insulin level,insulin resistance index(HOMA-IR),body mass index(BMI) and blood pressure were measured in all subjects. The correlation of these parameters were analyzed.Results:①The apelin-12 levels in patients with T2DM complicated by hypertension were significantly lower compared with normal controls and those with T2DM only(P<0.05orP<0.01),the apelin-12 level of patients with T2DM were higher than those in control group (P<0.05).②The TNF-αlevels in patients with T2DM and hypertension were significantly higher compared with the control group and those with T2DM (P<0.05orP<0.01),the TNF-αlevel of patients with T2DM only were significantly higher than those in control group(P<0.05).③The variable correlations showed a negative correlation between the plasma apelin-12 level and WHR,FINS,HOMA-IR,TG,SBP,TNF-α,a positive correlation between it and the HDL-C. Multiple regression showed WHR,HOMA-IR,TG,TNF-αwere equal predicators of plasma apelin-12 level.Conclusion: The plasma level of apelin-12 increased in the group of T2DM and decreased in the group of T2DM with hypertension.Apelin-12 is correlated with obesity,insulin resistance and inflammation. A speculation can be drew that the apelin-12 may contribute to the development of IR,T2DM and hypertension.