Effects Of Entecavir On HBV DNA And TGF-β1 In Serums Of Patients Chronic Hepatitit B

Objective:To investigate hepatitis B viral load(HBV DNA) and serum TGF-β1 changes in chronic hepatitis B patients before and after entecavir treatment,to understand the effect of entecavir, in order to provide a reference the clinical application of entecavir treat chronic hepatitis B.Methods:There are enticavir test group and control group who 63 cases with chronic hepatitis B patients are selected randomly.Test group 33 cases,including 9 cases of mild,17 cases of moderate,7 cases of severe patients.Entecavir 0.5mg once a day,while the general hepatoprotective drug are given;Control group 30 cases, including 13 cases of mild,12 cases of moderate,5 cases of severe patients.The general hepatoprotective drug are given. To observe the changes in Serum HBV DNA and TGF-(31 when be prepared treatment,treatment in 3 months,in 6 months respectively. With hepatitis B viral load and TGF-β1 as the main indicators used SPSS13.0 system software for statistical analysis,comparing between the changes before and after treatment.Results:Entecavir test group includ chronic hepatitis B mild, moderate and severe patients whoes Serum HBV DNA are decreased. There are statistically significant difference in Serum HBV DNA that compare treatment in 3 months and in 6 months with be prepared treatment (p<0.05). Entecavir test group includ chronic hepatitis B moderate and severe patients whoes serum TGF-β1 are decreased. There are statistically significant difference in chronic hepatitis B severe patients whoes serum TGF-β1 that compare treatment in 6 months with be prepared treatment(p<0.05). There are statistically significant difference in test group and control group (chronic hepatitis B mild, moderate and severe patients) of serum HBV DNA comparison when they are treatment in 6 months(p<0.05). There are statistically significant difference in test group and control group that chronic hepatitis B severe patients of serum TGF-β1 comparison when they are treatment in 6 months (p<0.05).Conclusions:Entecavir have influence on chronic hepatitis B patients of serum HBV DNA and TGF-β1 levels.There are a significant decreased in chronic hepatitis B mild,moderate and severe patients of serum HBV DNA. There are a significant decrease in chronic hepatitis B severe patients of serum TGF-β1. The chronic hepatitis B severe patients treated by enticavir is better.