The Clinical Research Of Contrast-induced Nephropathy After Primary Percutaneous Coronary Intervention In Patients With Acute Coronary Syndrome

Objective:To observer alterations of baseline renal functional in patients with acute coronary syndrome (ACS) and its clinic adverse events after percutaneous coronary intervention(PCI),and to explore the related factors of contrast-indeced nephropathy (CIN) and their effects on the prognosis of patients. Methods:the data on 78 patients with ACS who received PCI form October 2006 to October 2009 and material integrity were enrolled to observed patients baseline renal function and their alteration 48-72 hours before and after PCI. And clinic adverse events 6-24 months after PCI. to analyzes the related factors of contrast-indeced nephropathy and their effects of its adverse events. Results:five patients(6.4%) had rendal dysfunction before PCI using Scr as the detective index., whereas (46.1%) Demonstrated renal dysfunction using Ccr as the index.Renal function deteriorated in patients(14%) after PCI. Resulting in contrast-induced nephropathy (CIN),4 of them Had normal baseline renal function and 10 were abnormal in Baseline renal function. The incidence of CIN was hinger in those with chronic kidney diease or heart failure, old age,diabetes mellitus (Dm), receiving high dose of contrast media or urgent PCI. Average hospital stay was longer, and the incidences of clinic adverse events and overall mortality were hinger in CIN group than in non-CIN group (P<0.05). Conclusion:Abnormal baseline renalfunction or chronic kidney disease, heart failure, old age, use of high dose of contrast media, Dm, and urgent PCI are the relatd factors for deveioping CIN after PCI, CIN can significantly prolong length of hospital stay, incease the incidences of Adverse events and mortality.