| Objective To study the dynamic changes and clinical significance of the content of serum free fatty acids in patients with acute cerebral infarction by monitoring serum level of free fatty acids. Methods After 1-2 days and 7 days of acute cerebral infarction, serum level of FFA were detected by using Glycerol oxidase assay in 40 patients and 19 patients with acute cerebral infarction and 20 cases in control group.serum level of free fatty acids after acute cerebral infarction were compared with the control group. Results The serum leve of FFA was increased in the patients with acute cerebral infarction,They were all significantly higher than those in control group (P<0.01). Serum level of FFA were respectively (455.8±161.0)μmol/L and (292.5±121.8)μmol/L after onset of acute cerebral infarction in 2 days and 7 days and significantly higher than those in control group (122.8±15.2)μmol/L. Serum level of FFA in 2 days after onset of acute cerebral infarction was significantly higher than those in 7 days (P<0.01). FFA levels were different significantly among different patients with varied clinical features. FFA levels in the severe cases were higher than those of the intermediate and mild case (P< 0.01), The serum level of F F A in intermediate case were higher than those of the mild case (P<0.01). Conclusion The serum levels of FFA was increased after acute cerebral infarction,and declined when the condition of acute cerebral infarction was improved.Serum level of FFA was correlated with the degree of neurological deficit in cerebral infarction patients. the more severe condition of acute cerebral infarction would happen with higher levels of free fatty acids,The FFA levels of patients with cerebral infarction was helpful to evaluate patients condition and prognosis.
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