Molecular Targeted Therapy Of Gastric Cancer

Gastric cancer is the second leading cause of cancer mortality worldwide and is a major cause of cancer death in China.Recent improvements in both surgical techniques and adjuvant/neoadjuvant chemotherapy,radiotherapy or both have increased the survival rate of patients with early-stage disease.As most cases of gastric cancer are in the advanced stage of the disease when they are first diagnosed,patients receiving conventional therapies have poor prognosis.An emerging modality called tumor molecular targeted therapy provides promise and insight to combat this malignancy.These therapeutic strategies include epidermal growth factor receptor inhibitors,Her-2 receptor inhibitors,angiogenesis inhibitors,cell cycle inhibitors and apoptosis promoters.This review that presents a brief introduction to molecular targeted therapy of gastric cancer was intended to play a guidance in the therapy of advanced gastric cancer.Its significance is to prolong survival time and improve life quality of patients.