Clinical Study Of Early Hematoma Growth In Hypertensive Intracerebral Hemorrhage

Objective: To explore the clinical characteristics and correlative factors of early hematoma growth in hypertensive intracerebral hemorrhage(HICH). Methods: To review the clinical data of the 285 patients with HICH in the First Affiliated Hospital Xinjiang Medical University from January 2007 to May 2009. Divide all the patients into two groups according to having early hematoma growth or not. And the data of the two groups were compared. Results: 285 patients within 24 hours after onset were included. 77 patients (27.02%) were demonstrated hematoma growth. The rate of hematoma growth of patients with HICH was higher in 6 hours after onset than that from 6 to 24 hours after onset. There were significant differences between two groups (P=0.000);The mean value of systolic blood pressure, diastolic blood pressure and pulse pressure were all higher in the enlarged group than that in the non-enlarged group. And there were significant differences between two groups (P≤0.005);Multivariate analysis demonstrated that the course of hypertension, first pulse pressure, early using mannitol, the dosis of mannitol in 24h, Glasgow Coma Scale(GCS), drinking and the site of hematoma, the shape of hematoma were correlative with hematoma enlargement. The rate of surgical operation and mortality were all significantly higher in the enlarged group than that in the non-enlarged group. There were significant differences between two groups (P=0.000). Conclusion: 1.The rate of hematoma growth in the study was 27.02%. 2. The hematoma growth in HICH was almost happened in 6 hours after onset. 3. Multiple risk factors and mechanisms result in hematoma growth in HICH. 4. The prognosis for patients with early hematoma growth in HICH was poor and the mortality rate for these patients was high.