Neonatal Ventilator-associated Pneumonia: Risk Factors And Pathogens Profile

Objective: To investigate the risk factors, pathogen distribution and drug sensitivity of neonatal ventilator-associated pneumonia(VAP).Methods: Collecte the clinical data of all mechanical ventilation (>48h) patients admitted to the neonatology of Children's Hospital of Chongqing Medical University from may 2006 to may 2009. The incidence of VAP, the risk factors and pathogenic bacteria culture results were retrospectively analyzed .Results: The morbidity of VAP was 46.30% and the mortality was 22.34%. Univariate analysis showed that birth weight, gestational age, the number of tracheal intubation was related to the occurrence of VAP. Multivariate Logistic regression analysis showed that the number of tracheal intubation and birth weight were independent risk factors for VAP. VAP patients hospitalized longer than non-VAP patients. 116 strains of bacterium were found from the total 94 patients with VAP, from which 75 strains (64.65%) were Gram-negative bacill (GNB) 27 strains (23.28) were gram-positive cocci (GPC), 14 strains of fungi (12.07%). The most common pathogens were Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa. The antibiotics-sensitivity showed multidrug resistance to commonly used antibiotics, only part of the antibiotic-sensitive.Conclusions: The morbidity and mortality of VAP were very high, the incidence of VAP was related to birth weight, gestational age, the number of endotracheal intubation and other factors. Comprehensive treatment should be used to prevent the incidence of VAP. The main VAP pathogenic bacterium was gram negative bacilli. The multi-drug resistant pathogenic bacterium are common. So the rational use of antibiotics according to drug sensitivity is important in treating VAP.