| Objective: To observe the effects of pioglitazone (PIG) on blood lipids , high sensitive C-reactive protein (hs-CRP), urine albumin excretory rate (UAER) ,and bone mineral density (BMD) in patients with type 2 diabetes mellitus(T2DM). Methods: Fifty T2DM patients with poorly controlled blood glucose were given PIG for 12 weeks in our hospital between March 2009 and January 2010; The changes of of body height, body weight, blo- od pressure, fasting blood glucose (FPG), fasting insulin (FINS), blood lipids, hs-CRP , UAER , and BMD were measured in patients at the baseline and 12weeks after the therapy. Homeostasis model assessment indexes (HOMA-IR) was calculated by the HOMA model. Body mass index (BMI) was also calculated. For all data, t test or Rank sum test were con- duct. Results:1.There was a significant decrease in FPG,FINS,HOMA-IR, triglyceride (T G), hs-CRP and UAER (P < 0.05) after PIG treatment for 12 weeks; 2. The high-density lioprotein-cholesterol (HDL-C) level increased compared to the baseline (P <0.05). 3. However ,there was no signficant difference in BMI, blood pressure, totalcholesterol (TC) , low-density lioprotein-cholesterol (LDL-C), Lp(a),BMD(P >0.05). Conclusion: The treatment of PIG can not only improve insulin sensitivity but also decrease the level of hs-CRP and UREA. PIG can prevent the development of diabetes melleius and diabetic nephropathy. PIG has no impact on BMD during the treatment in short time.
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