The Comparsion Of Molecular Genetic Basis Of Physichal And Relational Aggression: An Analysis Of Genes Involved In Dopamine Systems

Physical aggression and relational aggression are two forms of aggressive behavior, researchers have provided evidence that there is substantial overlap between physical and relational aggression, but they are distinct constructs(Crick et al.,2007; Little et al.,2003). The melecular genetics of physical aggression is developing fast, and researchers are especially interested in the genes involved in dopamine systems. Although there is not an agreement about the results, some genes may affect the aggressive behavior someway. Thoes reserchers define aggression almost as physical aggressive behavior, and their subjects were mostly chosen from the abnormal groups of people who have specific illnesss like schizophrenia. Studyies about relational aggression and typical genes are very limited, and there is almost no one doing this job, which is comparing the molecular genetic basis of physical and relational aggression. In this paper, we are the first group to find if there are any diffrences between the physical and relational aggression on the genes of dopamine systems, MAOA and COMT, which have some single nucleotide polymorphism in them.A cluster sampling method from Jinan,8 Shandong primary school grade 4,5 students were chosen as the samples, a total of 2,747 people, about evenly divided between girls and boys. Peer assessment method with 2,747 children in the physical aggression, relational aggression evaluation, and aggression on young boys and girls separately standardized scores, standard scores> 1 were as highly aggressive individuals with normal individuals. Eventually selected a total of 452 subjects, including 283 boys (accounting for 62.61%), girls 169 (accounting for 37.39%). These 452 children, MAOA (rs6323) and COMT (rs4680) single nucleotide polymorphisms were determined. The MAOA (rs6323) and COMT (rs4680) gene polymorphism, gender as independent variables to physical aggression and relational aggression score as the dependent variable, multivariate analysis of variance to examine whether relational aggression and physical aggression in the two genes. There are differences of polymorphism.Our result indicated that, MAOA gene was not affect neither physical nor relational aggression. For boys, there is no significant differences between the rs4680 in COMT gene and both of the two types of aggression. For girls, the G allelle carriers performed significant more physical aggression than the A homozygote carriers, however, there is some diffrences about relational aggression. The girls whom having the AA genes are still at a low level of relational aggression, and the GA carriers, they are still at a high level,but the GG carriers are not significant to any of the other types.