| 100-meter race is one of the most famous sports which have long history, intense competition and high visual effects. There are many factors to affect the evolution of 100-meter world records, but the invisible factors are unknown, for example, doping. In the 21st century, the doping cases in 100-meter race often were reported, so when the men's 100-meter world records were renewed frequently by Jamaican athlete, Bolt, many authorities and media had a question whether he has an affair with doping. However, some experts said, doing didn't benefit to improving 100-meter race performance. So what is the truth? Faced these problems, this paper analyzed the obvious factors of improving 100-meter race performance and world record, and proposed that doing was the invisible factor of changing 100-meter world record, moreover, demonstrated doing affected the evolution of 100-meter world record based on the analysis of the doping cases in 100-meter race and the summary of doping research results. Finily, the findings reviewed the latest progress of doping tests and proposed to use reasonably gene technology and to develop sports nutrition supplements. Main conclution:(1) The use of doping improved the range of breaking 100-meter world record, shorten the life of the world record in a certain period, accelerate the evolution of a world record;(2) The use of doping in 100-meter race can be divided into three phases that some of the doping did help improve the 100-meter race;(3) A few of doping were used together, particularly the new synthetic steroid hormones and peptide hormones, is the characteristic and trend of doping used at present; (4) Gene doping is the potential threat on 100-meter race;(5) Reason use of modern gene technology and the power development of sports nutrition supplements are the effective ways of preventing the prevalence of doping and improving doping control.
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