| Backgrounds:The benign prostatic hyperplasia (BPH), commonly known as hypertrophy of the prostate, is common in the patients with lower urinary tract symptoms,prostate volume increases and bladder outlet obstruction.It is a common disease in the urology and andrology.The incidence of the disease increases with the age of the elderly men.The disease can be seen in men over 40 years of age,and the incidence of men over the age of 60 is over 40%.The current clinical treatment of BPH can be divided into conservative treatment and surgical treatment.Surgical treatment is divided into transurethral resection of the prostate, laparoscopic prostatectomy, holmium laser prostatectomy and other surgical methods.For conservative treatment, the first choice of the modern medicine is drug oral.Alpha receptor blockers,5 alpha reductase inhibitors and plant preparations are commonly used.The traditional Chinese medicine also includes drug therapy, acupuncture and moxibustion therapy, external therapy and other therapies.According to a large number of relevant documents in recent years, the traditional Chinese medicine theraps have many advantages such as exact curative effect, simple operation, high safety, fast acting, low cost.It is worth to be done further clinical validation and promotion.In addition, there are more than 80% of BPH patients whose serum PSA level is higher than normal, and the related documents of the effect of traditional Chinese medicine on BPH patients with abnormal serum PSA is very few.Purpose:Through the evidence-based medicine method to observe the effect of "Qianlie Shutong Granule" on clinical BPH patients and its influence on the level of serum PSA.Methods:60 cases of benign prostatic hyperplasia in the Wangjing Hospital of Chinese Academy of traditional Chinese medicine will be selected and randomly divided into treatment group(30 cases) and control group(30 cases).The treatment group will be given "Qianlie Shutong Soup", the control group will be treated with Finasteride Tablets and Qianlie Beixi Capsules, and the course of treatment will be 8 weeks.Before treatment and 8 weeks after treatment, the indexes will be measured and the data will be analyzed by using SPSS20.0 software.The experimental data will be carried out with two-sided test.Measurement data using t test, count data using chi-square test.Results:In IPSS:Before and after treatment in the treatment group, compared with the t test, t=9.112, P<0.001, the difference was statistically significant.And in the control group, after t test, t=8.296, P<0.001, the difference was also statistically significant.The difference of the two groups during the 8 weeks’ treatment was compared by t test, t=0.295, P=0.004<0.01, the difference was statistically significant, the treatment group than the control group has more advantages.In QOL:Before and after treatment in the treatment group, compared with Wilcoxon rank sum test, Z=-4.300, P<0.001, the difference was statistically significant.And in the control group,after Wilcoxon rank sum test, Z=-4.388, P<0.001,the difference was also statistically significant..The difference of the two groups during the 8 weeks’treatment was compared by Wilcoxon rank sum test,Z=-0.303, P=0.754>0.05, the difference was not statistically significant.In residual urine volume:Before and after treatment in the treatment group, compared with the t test, t=7.151, P<0.001, the difference was statistically significant.And in the control group, after t test, t=8.034, P<0.001, the difference was also statistically significant.The difference of the two groups during the 8 weeks’treatment was compared by t test, t=0.105, P=0.917>0.05, the difference was not statistically significant.In prostate volume:Before and after treatment in the treatment group, after t test, t=2.179, P=0.038<0.05, the difference was statistically significant.And in the control group, after t test, t=2.056, P=0.049<0.05, the difference was also statistically significant.The difference of the two groups during the 8 weeks’ treatment was compared by t test, t=-0.335, P=0.739>0.05, the difference was not statistically significant.In PSA.Before and after treatment in the treatment group, after t test, t=4.349, P<0.001, the difference was statistically significant.And in the control group, after t test, t=2.175, P=0.038<0.05, the difference was also statistically significant.The difference of the two groups during the 8 weeks’treatment was compared by t test, t=2.120, P=0.038<0.05, the difference was statistically significant, compared with the control group, the treatment group had more advantages.Conclusion:(1)Both the treatment group and the control group could improve the clinical symptoms and quality of life of BPH patients, but the treatment group was significantly better than that of the control group, which could significantly improve the clinical symptoms.(2)There was no significant difference between the two groups in the efficacy of reducing the volume of prostate.(3)In improving the abnormal prostate specific antigen in patients with benign prostatic hyperplasia, the treatment group and the control group were effective, but the effect of the treatment group was more obvious. |
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